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Title:
CONDENSED RING GROUP AZACYCLOBUTYL TRIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2018/113694
Kind Code:
A1
Abstract:
The present invention relates to a condensed ring group azacyclobutyl triazole derivative, a preparation method therefor and use thereof in medicine. In particular, the present invention relates to a novel condensed ring group azacyclobutyl triazole derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, use thereof as a therapeutic agent, in particular as an oxytocin antagonist, and use thereof in the preparation of a medicament used for treating or preventing a disease or a condition that is known or can exhibit a beneficial effect of inhibiting oxytocin. The definition for each substituent in general formula (I) is the same as that in the description.

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Inventors:
LI XIN (CN)
HE WEI (CN)
WANG BIN (CN)
ZHANG ZHIGAO (CN)
HE FENG (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2017/117421
Publication Date:
June 28, 2018
Filing Date:
December 20, 2017
Export Citation:
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Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/14; A61K31/397; A61K31/4196; A61P15/00
Domestic Patent References:
WO2005028452A12005-03-31
WO2005082866A22005-09-09
WO2006077496A12006-07-27
WO2006092731A12006-09-08
WO2006100588A12006-09-28
WO2006100557A12006-09-28
WO2009065919A22009-05-28
WO2012094462A22012-07-12
WO2015180612A12015-12-03
Foreign References:
CN101107243A2008-01-16
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See also references of EP 3560918A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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