Title:
CONJUGATE OF ANTI-CTLA-4 ANTIBODY ACTIVATED BY TUMOR MICROENVIRONMENT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/241632
Kind Code:
A1
Abstract:
Provided are a conjugate of an anti-CTLA-4 antibody activated by a tumor microenvironment and an application thereof. The conjugate of the present invention has the following structure: R1-R2-R3-L-R4-S-cys-R5, wherein R1, R2, R3, L, R4, and R5 each represent structures such as different functional groups, linkers, chemical bonds, and CTLA-4 antibodies. The conjugate of the present invention is a dual-activated conjugate, which can improve the targeting efficacy of the anti-CTLA-4 antibody while overcoming the drug resistance of the antibody and reducing toxicity.
Inventors:
LIU CHEN (CN)
LIU YUAN (CN)
LIU YUAN (CN)
Application Number:
PCT/CN2023/100258
Publication Date:
December 21, 2023
Filing Date:
June 14, 2023
Export Citation:
Assignee:
YAFEI SHANGHAI BIOLOGY MEDICINE SCIENCE & TECH CO LTD (CN)
International Classes:
A61K47/60; A61P35/00; C07K5/08
Foreign References:
| CN111670051A | 2020-09-15 | |||
| CN104147612A | 2014-11-19 | |||
| CN113274507A | 2021-08-20 | |||
| US20190062272A1 | 2019-02-28 | |||
| US20190099499A1 | 2019-04-04 | |||
| US20160310612A1 | 2016-10-27 |
Other References:
D. H. CHARYCH, U. HOCH, J. L. LANGOWSKI, S. R. LEE, M. K. ADDEPALLI, P. B. KIRK, D. SHENG, X. LIU, P. W. SIMS, L. A. VANDERVEEN, C: "NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models", CLINICAL CANCER RESEARCH, ASSOCIATION FOR CANCER RESEARCH, US, vol. 22, no. 3, 1 February 2016 (2016-02-01), US, pages 680 - 690, XP055432446, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-15-1631
ZENG ZILING, ZHANG CHI, HE SHASHA, LI JINGCHAO, PU KANYI: "Activatable Cancer Sono‐Immunotherapy using Semiconducting Polymer Nanobodies", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 34, no. 28, 1 July 2022 (2022-07-01), DE , XP093117984, ISSN: 0935-9648, DOI: 10.1002/adma.202203246
ZENG ZILING, ZHANG CHI, HE SHASHA, LI JINGCHAO, PU KANYI: "Activatable Cancer Sono‐Immunotherapy using Semiconducting Polymer Nanobodies", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 34, no. 28, 1 July 2022 (2022-07-01), DE , XP093117984, ISSN: 0935-9648, DOI: 10.1002/adma.202203246
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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