Title:
CONJUGATE OF ANTIBODY AND FUNCTIONAL SUBSTANCE OR SALT THEREOF, AND ANTIBODY DERIVATIVE AND COMPOUND OR SALTS THEREOF TO BE USED IN PRODUCING CONJUGATE OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/054706
Kind Code:
A1
Abstract:
The present invention provides a conjugate of an antibody and a functional substance, said conjugate having excellent desired properties, or a salt thereof. More particularly, the present invention provides a conjugate of an antibody and a functional substance, said conjugate containing a structural unit represented by formula (1) [wherein: Ig represents an immunoglobulin unit containing two heavy chains and two light chains and bonded to LA adjacent to Ig via thiol groups in the side chains of a plurality of cysteine residues in the two heavy chains and two light chains; HG represents a hydrophilic group or a monovalent group containing a hydrophilic group; CS represents a divalent group containing a cleavable moiety; ring A represents a divalent aromatic ring group which may have a substituent (wherein the divalent aromatic ring group constitutes a π-electron conjugated system together with the aforesaid cleavable moiety); V represents an oxygen atom, a sulfur atom or an amino(NH) group; LA and LB independently represent a divalent group; D represents a functional substance; and the average number n of the aforesaid bonds per immunoglobulin unit is 1.5 or more] or a salt thereof, and substances related thereto.
Inventors:
MATSUDA YUTAKA (JP)
WATANABE TOMOHIRO (JP)
HATADA NORIKO (JP)
FUJII TOMOHIRO (JP)
WATANABE TOMOHIRO (JP)
HATADA NORIKO (JP)
FUJII TOMOHIRO (JP)
Application Number:
PCT/JP2022/036835
Publication Date:
April 06, 2023
Filing Date:
September 30, 2022
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
C07K16/00; A61K31/165; A61K39/395; A61K45/00; A61K47/65; A61K47/68; A61K49/00; A61P35/00; A61P43/00; C07K5/06; C07K5/08; C07K7/06; C07K19/00
Domestic Patent References:
| WO2015038426A1 | 2015-03-19 | |||
| WO2022058548A1 | 2022-03-24 | |||
| WO2018199337A1 | 2018-11-01 | |||
| WO2019240288A1 | 2019-12-19 | |||
| WO2019240287A1 | 2019-12-19 | |||
| WO2020090979A1 | 2020-05-07 | |||
| WO2014057687A1 | 2014-04-17 | |||
| WO2015038426A1 | 2015-03-19 | |||
| WO2002083180A1 | 2002-10-24 | |||
| WO2004043493A1 | 2004-05-27 | |||
| WO2005112919A2 | 2005-12-01 | |||
| WO2004010957A2 | 2004-02-05 | |||
| WO2019240287A1 | 2019-12-19 | |||
| WO2018218004A1 | 2018-11-29 |
Foreign References:
| JP2016508136A | 2016-03-17 | |||
| JP2018510864A | 2018-04-19 | |||
| JP2018503639A | 2018-02-08 | |||
| JP2019524845A | 2019-09-05 | |||
| JP2020525404A | 2020-08-27 | |||
| JP2020534030A | 2020-11-26 | |||
| US6214345B1 | 2001-04-10 | |||
| US5622929A | 1997-04-22 | |||
| US5122368A | 1992-06-16 | |||
| US5824805A | 1998-10-20 | |||
| US20060074008A1 | 2006-04-06 | |||
| US20050238649A1 | 2005-10-27 |
Other References:
DORYWALSKA ET AL., BIOCONJUGATE CHEM., vol. 26, no. 4, 2015, pages 650 - 659
DORYWALSKA ET AL., MOL CANCER THER., vol. 15, no. 5, 2016, pages 958 - 70
LYON ET AL., NAT BIOTECHNOL., vol. 33, no. 7, 2015, pages 733 - 5
SHARPLESS K.B., ANGEW. CHEM. INT. ED., vol. 40, 2015, pages 2004
BERTOZZI C. R. ET AL., SCIENCE, vol. 291, 2001, pages 2357
BERTOZZI C. R. ET AL., NATURE CHEMICAL BIOLOGY, vol. 1, 2005, pages 13
G. LERICHEL. CHISHOLMA. WAGNER, BIOORGANIC & MEDICINAL CHEMISTRY., vol. 20, 2012, pages 571
FENG P. ET AL., JOUNAL OF AMERICAN CHEMICAL SOCIETY, vol. 132, 2010, pages 1500
SCHOENMARKS, R. G., JOURNAL OF CONTROLLED RELEASE, vol. 95, 2004, pages 291
DESIMONE, J. M., JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 132, 2010, pages 17928
THOMPSON, D. H., JOURNAL OF CONTROLLED RELEASE, vol. 91, 2003, pages 187
DUBOWCHIK ET AL., PHARM.THERAPEUTICS, vol. 83, 1999, pages 67 - 123
FEBS JOURNAL, vol. 287, 2020, pages 1936 - 1969
THE FEBS JOURNAL, vol. 287, 2020, pages 1936 - 1969
EXAMPLES AND CHEMISTRY SELECT, vol. 5, 2020, pages 8435 - 8439
G. J. L. BERNARDES ET AL., CHEM. REV., vol. 115, 2015, pages 2174 - 2195
G. J. L. BERNARDES ET AL., CHEM. ASIAN. J., vol. 4, 2009, pages 630
B. G. DAVIES ET AL., NAT. COMMUN, vol. 5, 2014, pages 4740
A. WAGNER ET AL., BIOCONJUGATE. CHEM, vol. 25, 2014, pages 825
ANAL. CHEM., vol. 91, no. 20, 2019, pages 12724 - 12732
CHEMISTRY SELECT, vol. 5, 2020, pages 8435 - 8439
NATURE COMMUNICATIONS, vol. 9, 2018, pages 2512
DORYWALSKA ET AL., MOL CANCER THER., vol. 15, no. 5, 2016, pages 958 - 70
LYON ET AL., NAT BIOTECHNOL., vol. 33, no. 7, 2015, pages 733 - 5
SHARPLESS K.B., ANGEW. CHEM. INT. ED., vol. 40, 2015, pages 2004
BERTOZZI C. R. ET AL., SCIENCE, vol. 291, 2001, pages 2357
BERTOZZI C. R. ET AL., NATURE CHEMICAL BIOLOGY, vol. 1, 2005, pages 13
G. LERICHEL. CHISHOLMA. WAGNER, BIOORGANIC & MEDICINAL CHEMISTRY., vol. 20, 2012, pages 571
FENG P. ET AL., JOUNAL OF AMERICAN CHEMICAL SOCIETY, vol. 132, 2010, pages 1500
SCHOENMARKS, R. G., JOURNAL OF CONTROLLED RELEASE, vol. 95, 2004, pages 291
DESIMONE, J. M., JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 132, 2010, pages 17928
THOMPSON, D. H., JOURNAL OF CONTROLLED RELEASE, vol. 91, 2003, pages 187
DUBOWCHIK ET AL., PHARM.THERAPEUTICS, vol. 83, 1999, pages 67 - 123
FEBS JOURNAL, vol. 287, 2020, pages 1936 - 1969
THE FEBS JOURNAL, vol. 287, 2020, pages 1936 - 1969
EXAMPLES AND CHEMISTRY SELECT, vol. 5, 2020, pages 8435 - 8439
G. J. L. BERNARDES ET AL., CHEM. REV., vol. 115, 2015, pages 2174 - 2195
G. J. L. BERNARDES ET AL., CHEM. ASIAN. J., vol. 4, 2009, pages 630
B. G. DAVIES ET AL., NAT. COMMUN, vol. 5, 2014, pages 4740
A. WAGNER ET AL., BIOCONJUGATE. CHEM, vol. 25, 2014, pages 825
ANAL. CHEM., vol. 91, no. 20, 2019, pages 12724 - 12732
CHEMISTRY SELECT, vol. 5, 2020, pages 8435 - 8439
NATURE COMMUNICATIONS, vol. 9, 2018, pages 2512
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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