Title:
CONJUGATE AND BLOCK COPOLYMER CONTAINING FLUORESCENT CHROMOPHORE AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/205286
Kind Code:
A1
Abstract:
Provided is a conjugate containing a fluorescent chromophore, which has any structure selected from C1 to C3. The conjugate containing the fluorescent chromophore provided by the present invention comprises one fluorescent chromophore and two highly reactive groups R1 and R2 linked to the fluorescent chromophore by a covalent bond. The fluorescent chromophore in the conjugate initially has no or only weak fluorescence emission capability, and only after the two highly reactive groups react together with the corresponding molecule, the fluorescent chromophore has strong fluorescence emission. Therefore, the efficiency of conjugation of drug molecules to targeting molecules can be monitored in situ by the infrared fluorescence emission intensity and applied to the target-mediated drug delivery.
Inventors:
LIU SHIYONG (CN)
LIU GUHUAN (CN)
JIANG YANYAN (CN)
LIU GUHUAN (CN)
JIANG YANYAN (CN)
Application Number:
PCT/CN2017/084503
Publication Date:
November 15, 2018
Filing Date:
May 16, 2017
Export Citation:
Assignee:
UNIV SCIENCE & TECHNOLOGY CHINA (CN)
International Classes:
C07D311/16; A61K31/704; A61K47/54; A61K47/62; A61K49/00; A61P35/00; C07D405/06; C07H15/252; C07K14/585; C07K14/765; C09K11/06
Foreign References:
| CN104004149A | 2014-08-27 |
Other References:
DEHUI WANG ET AL: "Aminonaphthalimide-based imidazolium podands for turn-on fluorescence sensing of nucleoside polyphosphates", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 8, no. 13, 1 January 2010 (2010-01-01), pages 2923, XP055612374
SATO S. ET AL: "Synthesis and Spectral Properties of Polymethine-cyanine Dye-nitroxide Radical Hybrid Compounds for Use as Fluorescence Probes to Monitor Reducing Species and Radicals", SPECTROCHIMICA ACTA PART A, vol. 71, no. 5, 31 December 2009 (2009-12-31), pages 2032 - 2039, XP025675188
SATO S. ET AL: "Synthesis and Spectral Properties of Polymethine-cyanine Dye-nitroxide Radical Hybrid Compounds for Use as Fluorescence Probes to Monitor Reducing Species and Radicals", SPECTROCHIMICA ACTA PART A, vol. 71, no. 5, 31 December 2009 (2009-12-31), pages 2032 - 2039, XP025675188
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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