Title:
A CONJUGATE COMPRISING OXYNTOMODULIN AND AN IMMUNOGLOBULIN FRAGMENT, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/173422
Kind Code:
A9
Abstract:
The present invention relates to a conjugate comprising oxyntomodulin, an immunoglobulin Fc region, and non-peptidyl polymer wherein the conjugate being obtainable by covalently linking oxyntomodulin to immunoglobulin Fc region via non-peptidyl polymer, and a pharmaceutical composition for the prevention or treatment of obesity comprising the conjugates. The conjugate comprising oxyntomodulin and the immunoglobulin Fc of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis without side-effects, unlike native oxyntomodulin, and also shows excellent receptor-activating effects and long-term sustainability, compared to native oxyntomodulin. Thus, it can be widely used in the treatment of obesity with safety and efficacy.
Inventors:
JUNG SUNG YOUB (KR)
KIM DAE JIN (KR)
PARK SUNG HEE (KR)
WOO YOUNG EUN (KR)
CHOI IN YOUNG (KR)
KWON SE CHANG (KR)
KIM DAE JIN (KR)
PARK SUNG HEE (KR)
WOO YOUNG EUN (KR)
CHOI IN YOUNG (KR)
KWON SE CHANG (KR)
Application Number:
PCT/KR2012/004722
Publication Date:
March 14, 2013
Filing Date:
June 15, 2012
Export Citation:
Assignee:
HANMI SCIENCE CO LTD (KR)
JUNG SUNG YOUB (KR)
KIM DAE JIN (KR)
PARK SUNG HEE (KR)
WOO YOUNG EUN (KR)
CHOI IN YOUNG (KR)
KWON SE CHANG (KR)
JUNG SUNG YOUB (KR)
KIM DAE JIN (KR)
PARK SUNG HEE (KR)
WOO YOUNG EUN (KR)
CHOI IN YOUNG (KR)
KWON SE CHANG (KR)
International Classes:
C07K14/575; A61K38/26; A61K47/48; A61P3/04; C07K17/00
Attorney, Agent or Firm:
SON, Min (6th Floor 36, Teheran-ro 87 gil, Gangnam-gu, Seoul 135-973, KR)
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Claims: