Title:
CONJUGATE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/138682
Kind Code:
A1
Abstract:
The present invention relates to a compound of formula (I), or a tautomer, stereoisomer, pharmaceutically acceptable salt or isotopic variant thereof. The compound represented by formula (I) or the tautomer, stereoisomer, pharmaceutically acceptable salt or isotopic variant thereof is used as a novel linker compound, and can be used for preparing an ADC drug having a high DAR value. The present invention also relates to an ADC drug prepared by the linker.
Inventors:
CHEN JIAN (CN)
ZHAO HAIBO (CN)
ZHAO HAIBO (CN)
Application Number:
PCT/CN2023/073332
Publication Date:
July 27, 2023
Filing Date:
January 20, 2023
Export Citation:
Assignee:
BEIJING CHEMPION BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07C237/08; A61K47/60; A61K47/66; A61K47/68; A61P35/00
Domestic Patent References:
| WO2022161452A1 | 2022-08-04 | |||
| WO2021257917A1 | 2021-12-23 | |||
| WO2021072246A1 | 2021-04-15 | |||
| WO2022015656A1 | 2022-01-20 |
Foreign References:
| CN110234357A | 2019-09-13 | |||
| EP2913064A1 | 2015-09-02 | |||
| CN101541332A | 2009-09-23 | |||
| CN109206610A | 2019-01-15 | |||
| CN110835316A | 2020-02-25 | |||
| DE10326303A1 | 2004-12-30 | |||
| US20130052130A1 | 2013-02-28 | |||
| US20170239364A1 | 2017-08-24 |
Other References:
GIESE MATTHEW, DAVIS PAUL D., WOODMAN ROBERT H., HERMANSON GREG, POKORA ALEX, VERMILLION MELISSA: "Linker Architectures as Steric Auxiliaries for Altering Enzyme-Mediated Payload Release from Bioconjugates", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 32, no. 10, 20 October 2021 (2021-10-20), US , pages 2257 - 2267, XP093079996, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.1c00429
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
Download PDF: