Title:
CONJUGATED LINOLEIC ACID COMPOSITION AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2018/186327
Kind Code:
A1
Abstract:
The present invention provides a conjugated linoleic acid containing c9, t11 conjugated linoleic acids, wherein a mass ratio of total t10, c12 conjugated linoleic acids to total c9, t11 conjugated linoleic acids is below 0.25.
Inventors:
NATORI SYUNJI (JP)
Application Number:
PCT/JP2018/014062
Publication Date:
October 11, 2018
Filing Date:
April 02, 2018
Export Citation:
Assignee:
NATORI SYUNJI (JP)
KUSHIMA MITSUTAKA (JP)
KUSHIMA MITSUTAKA (JP)
International Classes:
A23K10/20; C11C1/02; A23K20/158; A23L33/12; A61K31/201; A61K35/64; C11B1/10
Foreign References:
| JPS5824450B2 | 1983-05-21 |
Other References:
RISERUS, U. ET AL.: "Effects of cis-9, trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men", THE AMERICAN JOURNAL OF CLINICAL NUTRITION, vol. 80, no. 2, 1 August 2004 (2004-08-01), pages 279 - 283, XP055558526, ISSN: 1938-3207, Retrieved from the Internet
CLEMENT, L. ET AL.: "Dietary trans-10, cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse", JOURNAL OF LIPID RESEARCH, vol. 43, no. 9, September 2002 (2002-09-01), pages 1400 - 1409, XP055558531, ISSN: 1539-7262, Retrieved from the Internet
AOKI, Y. ET AL.: "Activation of latent ribonuclease in the fat-body of fleshfly (sarcophaga peregrina) larvae on pupation", BIOCHEMICAL JOURNAL, vol. 196, no. 3, 15 June 1981 (1981-06-15), pages 699 - 703, XP055558535, ISSN: 1470-8728, Retrieved from the Internet
CLEMENT L. ET AL.: "Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse", J. LIPID RES., vol. 43, 2002, pages 1400 - 1409, XP055558531, DOI: 10.1194/jlr.M20008-JLR200
IP M.M. ET AL.: "The tl0,cl2 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium", CARCINOGENESIS, vol. 28, 2007, pages 1269 - 1276
HUNT W.T. ET AL.: "Protection of cortical neurons from excitotoxicity by conjugated linoleic acid", J. NEUROCHEM., vol. 115, 2010, pages 123 - 130
JOO N.E.PARK C.S.: "Inhibition of excitotoxicity in cultured rat cortical neurons by a mixture of conjugated linoleic acid isomers", PHARMACOL. RES., vol. 47, 2003, pages 305 - 310, XP055045051, DOI: 10.1016/S1043-6618(03)00008-2
LEE E. ET AL.: "Effect of conjugated linoleic acid, jo— calpain inhibitor, on pathogenesis of Alzheimer's disease", BIOCHIM. BIOPHYS. ACTA, vol. 1831, 2003, pages 709 - 718, XP055404279, DOI: 10.1016/j.bbalip.2012.12.003
GAMA M.A.S. ET AL.: "Conjugated linoleic acid-enriched butter improved memory and up-regulated phospholipse A2 encoding-genes in rat brain tissue", J. NEURAL TRANSM., vol. 122, 2015, pages 1371 - 1380
See also references of EP 3608390A4
CLEMENT, L. ET AL.: "Dietary trans-10, cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse", JOURNAL OF LIPID RESEARCH, vol. 43, no. 9, September 2002 (2002-09-01), pages 1400 - 1409, XP055558531, ISSN: 1539-7262, Retrieved from the Internet
AOKI, Y. ET AL.: "Activation of latent ribonuclease in the fat-body of fleshfly (sarcophaga peregrina) larvae on pupation", BIOCHEMICAL JOURNAL, vol. 196, no. 3, 15 June 1981 (1981-06-15), pages 699 - 703, XP055558535, ISSN: 1470-8728, Retrieved from the Internet
CLEMENT L. ET AL.: "Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse", J. LIPID RES., vol. 43, 2002, pages 1400 - 1409, XP055558531, DOI: 10.1194/jlr.M20008-JLR200
IP M.M. ET AL.: "The tl0,cl2 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium", CARCINOGENESIS, vol. 28, 2007, pages 1269 - 1276
HUNT W.T. ET AL.: "Protection of cortical neurons from excitotoxicity by conjugated linoleic acid", J. NEUROCHEM., vol. 115, 2010, pages 123 - 130
JOO N.E.PARK C.S.: "Inhibition of excitotoxicity in cultured rat cortical neurons by a mixture of conjugated linoleic acid isomers", PHARMACOL. RES., vol. 47, 2003, pages 305 - 310, XP055045051, DOI: 10.1016/S1043-6618(03)00008-2
LEE E. ET AL.: "Effect of conjugated linoleic acid, jo— calpain inhibitor, on pathogenesis of Alzheimer's disease", BIOCHIM. BIOPHYS. ACTA, vol. 1831, 2003, pages 709 - 718, XP055404279, DOI: 10.1016/j.bbalip.2012.12.003
GAMA M.A.S. ET AL.: "Conjugated linoleic acid-enriched butter improved memory and up-regulated phospholipse A2 encoding-genes in rat brain tissue", J. NEURAL TRANSM., vol. 122, 2015, pages 1371 - 1380
See also references of EP 3608390A4
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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