Title:
CONJUGATES COMPRISING AN ANTIBODY SPECIFIC FOR THE ED-B DOMAIN OF FIBRONECTIN AND THEIR USE FOR THE DETECTION AND TREATMENT OF TUMOURS
Document Type and Number:
WIPO Patent Application WO2003055917
Kind Code:
A3
Abstract:
The present invention relates to methods for diagnosis and treatment of tumours, using peptides for binding radionuclides. The peptides comprise an antigen- binding site for the extra domain B (ED-B) of fibronectin.
Inventors:
HILGER CHRISTOPH-STEPAN (DE)
BERNDORFF DIETMAR (DE)
DINKELBORG LUDGER (DE)
MOOSMAYER DIETER (DE)
NERI GIOVANNI (IT)
BERNDORFF DIETMAR (DE)
DINKELBORG LUDGER (DE)
MOOSMAYER DIETER (DE)
NERI GIOVANNI (IT)
Application Number:
PCT/EP2003/000009
Publication Date:
December 24, 2003
Filing Date:
January 02, 2003
Export Citation:
Assignee:
SCHERING AG (DE)
HILGER CHRISTOPH-STEPAN (DE)
BERNDORFF DIETMAR (DE)
DINKELBORG LUDGER (DE)
MOOSMAYER DIETER (DE)
NERI GIOVANNI (IT)
HILGER CHRISTOPH-STEPAN (DE)
BERNDORFF DIETMAR (DE)
DINKELBORG LUDGER (DE)
MOOSMAYER DIETER (DE)
NERI GIOVANNI (IT)
International Classes:
A61K38/00; A61K47/48; A61K51/00; C12N15/09; A61K51/08; A61K51/10; A61P35/00; C07K1/13; C07K14/78; C07K16/18; C07K16/44; C07K19/00; C12P21/02; A61K9/00; C12R1/84; (IPC1-7): C07K19/00; A61K47/48; A61K51/10; A61P35/00
Domestic Patent References:
| WO1999058570A2 | 1999-11-18 |
Other References:
MARTY CORNELIA ET AL: "Production of functionalized single-chain Fv antibody fragments binding to the ED-B domain of the B-isoform of fibronectin in Pichia pastoris.", PROTEIN EXPRESSION AND PURIFICATION, vol. 21, no. 1, February 2001 (2001-02-01), pages 156 - 164, XP002242574, ISSN: 1046-5928
GEORGE A J T ET AL: "RADIOMETAL LABELING OF RECOMBINANT PROTEINS BY A GENETICALLY ENGINEERED MINIMAL CHELATION SITE: TECHNETIUM-99M COORDINATION BY SINGLE-CHAIN FV ANTIBODY FUSION PROTEINS THROUGH A C-TERMINAL CYSTEINYL PEPTIDE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 92, no. 18, August 1995 (1995-08-01), pages 8358 - 8362, XP000891226, ISSN: 0027-8424
MARIANI GIULIANO ET AL: "A pilot pharmacokinetic and immunoscintigraphic study with the technetium-99m-labeled monoclonal antibody BC-1 directed against oncofetal fibronectin in patients with brain tumors.", CANCER, vol. 80, no. 12 SUPPL., 15 December 1997 (1997-12-15), pages 2484 - 2489, XP002242575, ISSN: 0008-543X
GEORGE A J T ET AL: "RADIOMETAL LABELING OF RECOMBINANT PROTEINS BY A GENETICALLY ENGINEERED MINIMAL CHELATION SITE: TECHNETIUM-99M COORDINATION BY SINGLE-CHAIN FV ANTIBODY FUSION PROTEINS THROUGH A C-TERMINAL CYSTEINYL PEPTIDE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 92, no. 18, August 1995 (1995-08-01), pages 8358 - 8362, XP000891226, ISSN: 0027-8424
MARIANI GIULIANO ET AL: "A pilot pharmacokinetic and immunoscintigraphic study with the technetium-99m-labeled monoclonal antibody BC-1 directed against oncofetal fibronectin in patients with brain tumors.", CANCER, vol. 80, no. 12 SUPPL., 15 December 1997 (1997-12-15), pages 2484 - 2489, XP002242575, ISSN: 0008-543X
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