CONTINUOUS POST-TREATMENT METHOD AND DEVICE FOR PENEM COMPOUND

Title:

CONTINUOUS POST-TREATMENT METHOD AND DEVICE FOR PENEM COMPOUND

Document Type and Number:

WIPO Patent Application WO/2021/072622

Kind Code:

A1

Abstract:

Provided are a continuous post-treatment method and device for a penem compound. The method comprises the following steps: S1, performing continuous extraction on a reaction crude product of a penem compound to obtain an extraction heavy phase and an extraction light phase; S2, performing continuous solid-liquid separation on the extraction heavy phase to obtain a liquid phase separation product; S3, performing continuous pH adjustment on the liquid phase separation product until the pH value is 6.1-6.3 to obtain a pH-adjusted solution; and S4, performing continuous crystallization treatment on the pH-adjusted solution by using a first crystallization solvent to obtain a penem compound product. The use of the method for post-treatment of a reaction crude product of a penem compound has the advantages of high treatment speed and high efficiency, and stable material properties and a low deterioration rate during treatment, and has better control over the yield and purity of a target product.

Inventors:

HONG HAO (US)
HONG LIANG (CN)
TAO JIAN (CN)
GUO JINHAI (CN)
CHENG XIAN (CN)
ZHANG YAN (CN)

Application Number:

PCT/CN2019/111198

Publication Date:

April 22, 2021

Filing Date:

October 15, 2019

Export Citation:

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Assignee:

ASYMCHEM LAB TIANJIN CO LTD (CN)

International Classes:

C07D477/02; B01D11/00; B01D11/04; C07D477/20

Foreign References:

CN102250145A	2011-11-23
CN102260264A	2011-11-30
CN102633801A	2012-08-15
CN108837558A	2018-11-20
CN109776646A	2019-05-21
CN207845524U	2018-09-11

Other References: