Title:
CONTRAST AGENT COMPOSITION FOR OPTICAL IMAGE, FOR EARLY DIAGNOSIS OF RHEUMATOID ARTHRITIS
Document Type and Number:
WIPO Patent Application WO/2021/096303
Kind Code:
A1
Abstract:
The present invention relates to a contrast agent composition which is for an optical image and used for the early diagnosis of rheumatoid arthritis, and a method for manufacturing same, and more particularly, to a contrast agent composition which is for diagnosing arthritis, and includes: gold nanoparticles; and a polyethylene glycol (PEG) coating layer formed so as to surround the surface of the gold nanoparticles. The contrast agent composition further includes a plurality of protein G's located on the gold nanoparticles and antibodies binding to the protein G's, or further includes peptides represented by SEQ ID NO: 1 and binding to the polyethylene glycol coating layer.
Inventors:
YOO KYUNG HWA (KR)
PARK YONG BEOM (KR)
LEE SUN MI (KR)
MUN CHIN HEE (KR)
YOON TAE JUN (KR)
PARK YONG BEOM (KR)
LEE SUN MI (KR)
MUN CHIN HEE (KR)
YOON TAE JUN (KR)
Application Number:
PCT/KR2020/016017
Publication Date:
May 20, 2021
Filing Date:
November 13, 2020
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
A61K49/00; A61K49/22
Foreign References:
| US20100028261A1 | 2010-02-04 | |||
| KR20130031557A | 2013-03-29 |
Other References:
ASHISH AGARWAL, HUANAN ZHANG, NICHOLAS A. KOTOV, XIA S. SHAO, JUSTIN R. RAJIAN, XUEDING WANG, DAVID L. CHAMBERLAND: "Dual-mode imaging with radiolabeled gold nanorods", JOURNAL OF BIOMEDICAL OPTICS, vol. 16, no. 5, 051307, 1 May 2011 (2011-05-01), pages 1 - 7, XP055811726, ISSN: 1083-3668, DOI: 10.1117/1.3580277
S CENTI , F RATTO , F TATINI , S LAI , R PINI: "Ready-to-use protein G-conjugated gold nanorods for biosensing and biomedical applications", JOURNAL OF NANOBIOTECHNOLOGY, vol. 16, 5, 19 January 2018 (2018-01-19), pages 1 - 11, XP055811730
JONATHAN VONNEMANN, NICOLAS BEZIERE, CHRISTOPH BÖTTCHER, SEBASTIAN B. RIESE, CHRISTIAN KUEHNE, JENS DERNEDDE, KAI LICHA, CLAUDIO V: "Polyglycerolsulfate Functionalized Gold Nanorods as Optoacoustic Signal Nanoamplifiers for In Vivo Bioimaging of Rheumatoid Arthritis", THERANOSTICS, vol. 4, no. 6, 1 January 2014 (2014-01-01), pages 629 - 641, XP055674362, ISSN: 1838-7640, DOI: 10.7150/thno.8518
LEE SUN-MI, KIM HYUNG JOON, HA YOU-JUNG, PARK YOUNG NYUN, LEE SOO-KON, PARK YONG-BEOM, YOO KYUNG-HWA: "Targeted Chemo-Photothermal Treatments of Rheumatoid Arthritis Using Gold Half-Shell Multifunctional Nanoparticles", ACS NANO, vol. 7, 29 November 2012 (2012-11-29), pages 50 - 57, XP055811734, ISSN: 1936-0851, DOI: 10.1021/nn301215q
S CENTI , F RATTO , F TATINI , S LAI , R PINI: "Ready-to-use protein G-conjugated gold nanorods for biosensing and biomedical applications", JOURNAL OF NANOBIOTECHNOLOGY, vol. 16, 5, 19 January 2018 (2018-01-19), pages 1 - 11, XP055811730
JONATHAN VONNEMANN, NICOLAS BEZIERE, CHRISTOPH BÖTTCHER, SEBASTIAN B. RIESE, CHRISTIAN KUEHNE, JENS DERNEDDE, KAI LICHA, CLAUDIO V: "Polyglycerolsulfate Functionalized Gold Nanorods as Optoacoustic Signal Nanoamplifiers for In Vivo Bioimaging of Rheumatoid Arthritis", THERANOSTICS, vol. 4, no. 6, 1 January 2014 (2014-01-01), pages 629 - 641, XP055674362, ISSN: 1838-7640, DOI: 10.7150/thno.8518
LEE SUN-MI, KIM HYUNG JOON, HA YOU-JUNG, PARK YOUNG NYUN, LEE SOO-KON, PARK YONG-BEOM, YOO KYUNG-HWA: "Targeted Chemo-Photothermal Treatments of Rheumatoid Arthritis Using Gold Half-Shell Multifunctional Nanoparticles", ACS NANO, vol. 7, 29 November 2012 (2012-11-29), pages 50 - 57, XP055811734, ISSN: 1936-0851, DOI: 10.1021/nn301215q
Attorney, Agent or Firm:
LEE, Jae Young (KR)
Download PDF:
Previous Patent: ELECTRIC DUST COLLECTOR AND AIR PURIFICATION SYSTEM USING SAME FOR SUBWAY STATION
Next Patent: GLP-1 RECEPTOR AGONIST AND USE THEREOF
Next Patent: GLP-1 RECEPTOR AGONIST AND USE THEREOF