Title:
CONTROLLED-RELEASE PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2013/147135
Kind Code:
A1
Abstract:
Provided is a controlled-release pharmaceutical composition which contains 4-{[(1R,2s,3S,5s,7s)-5-hydroxy-2-adamantyl]- amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, which is a compound of which the solubility in an acidic pH region is extremely different from that in a neutral pH region, as a medicinal agent, wherein the solubility of the medicinal agent can be maintained in a neutral pH region in the digestive tract after gastric emptying (e.g., the small intestine) and the controlled-release pharmaceutical composition exhibits a good oral absorption property and has high bioavailability.
The controlled-release pharmaceutical composition comprises 4-{[(1R,2s,3S,5s,7s)-5-hydroxy-2-adamantyl]amino}-1H- pyrrolo[2,3-b]pyridine-5-carboxamide or a pharmaceutically acceptable salt thereof, an acidic substance, a persaturation-maintaining agent, and a controlled-release base ingredient.
Inventors:
KOJIMA HIROYUKI (JP)
TAKAE SEIJI (JP)
YASUJI TAKEHIKO (JP)
SAKURAI ATSUSHI (JP)
IKEUCHI SATOMI (JP)
SAKO KAZUHIRO (JP)
TAKAE SEIJI (JP)
YASUJI TAKEHIKO (JP)
SAKURAI ATSUSHI (JP)
IKEUCHI SATOMI (JP)
SAKO KAZUHIRO (JP)
Application Number:
PCT/JP2013/059487
Publication Date:
October 03, 2013
Filing Date:
March 29, 2013
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
International Classes:
A61K31/437; A61K9/14; A61K9/16; A61K9/20; A61K9/48; A61K47/12; A61K47/32; A61K47/34; A61K47/38; A61P9/10; A61P11/06; A61P17/00; A61P25/28; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00; C07D471/04
Domestic Patent References:
| WO1994006414A1 | 1994-03-31 | |||
| WO2010038690A1 | 2010-04-08 |
Foreign References:
| JP2009522206A | 2009-06-11 | |||
| JP2004518676A | 2004-06-24 | |||
| JP2009504796A | 2009-02-05 | |||
| JPS62242615A | 1987-10-23 |
Attorney, Agent or Firm:
MORITA Kenichi et al. (JP)
Ken-ichi Morita (JP)
Ken-ichi Morita (JP)
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