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Title:
CONTROLLED-RELEASE SYSTEM OF ACTIVE PHARMACEUTICAL INGREDIENT AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/223753
Kind Code:
A1
Abstract:
Disclosed are a controlled-release dosage form with an absorption window in the upper gastrointestinal tract and a preparation method therefor, wherein the controlled-release dosage form comprises a controlled-release platform and a retention platform. The controlled-release platform is a pharmaceutical composition comprising a tablet core and a coating film; and the retention platform holds the controlled-release platform in the oral cavity. The operation steps of the controlled-release dosage form are as follows: placing the controlled-release platform in the retention platform, and fixing the retention platform on matching teeth in the oral cavity; taking out the controlled-release dosage form after 4-24 hours and replacing same with a new controlled-release platform; and re-fixing the retention platform on the matching teeth in the oral cavity to achieve the sustained and stable release of drugs.

Inventors:
DONG LIANG CHANG (CN)
CHEN XISHAN (CN)
SHI JINGMIN (CN)
ZHANG DANYONG (CN)
Application Number:
PCT/CN2019/088084
Publication Date:
November 28, 2019
Filing Date:
May 23, 2019
Export Citation:
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Assignee:
SHANGHAI WD PHARMACEUTICAL CO LTD (CN)
International Classes:
A61M31/00; A61K9/22; A61K31/198; A61P25/16
Foreign References:
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Other References:
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NYHOLM, D.ODIN, P.JOHANSSON, A.CHATAMRA, K.LOCKE, C.FREEMAN, S. ET AL.: "Stable levodopa plasma levels with jejunal infusion of levodopa-carbidopa intestinal gel in advanced Parkinson's disease patients [abstract", MOVEMENT DISORDERS, vol. 27, 2012, pages 410
See also references of EP 3797818A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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