Title:
COPOLYMER INCLUDING UNCHARGED HYDROPHILIC BLOCK AND CATIONIC POLYAMINO ACID BLOCK HAVING LATERAL CHAIN TO WHICH HYDROPHOBIC RADICAL IS PARTIALLY INTRODUCED, AND USE OF COPOLYMER
Document Type and Number:
WIPO Patent Application WO/2009/113645
Kind Code:
A8
Abstract:
Disclosed is a block copolymer including an uncharged hydrophilic polymer chain block, and a cationic polyamino acid chain block. In the copolymer, a hydrophilic polymer chain block is combined with an end of any one of main chains of the polyamino acid chain block via covalent binding, and a hydrophobic radical is combined with a lateral chain having 10 to70 amino acid repeating units in the polyamino acid chain block via covalent binding. The copolymer provides a stable aggregate with the siRNA, small molecule nucleic acid, under a physiologic condition.
Inventors:
KATAOKA KAZUNORI (JP)
NISHIYAMA NOBUHIRO (JP)
ISHII ATSUSHI (JP)
KATO YASUKI (JP)
MIYATA KANJIRO (JP)
KIM HYUNJIN (JP)
TAKEMOTO HIROYASU (JP)
NISHIYAMA NOBUHIRO (JP)
ISHII ATSUSHI (JP)
KATO YASUKI (JP)
MIYATA KANJIRO (JP)
KIM HYUNJIN (JP)
TAKEMOTO HIROYASU (JP)
Application Number:
PCT/JP2009/054824
Publication Date:
November 18, 2010
Filing Date:
March 06, 2009
Export Citation:
Assignee:
UNIV TOKYO (JP)
KATAOKA KAZUNORI (JP)
NISHIYAMA NOBUHIRO (JP)
ISHII ATSUSHI (JP)
KATO YASUKI (JP)
MIYATA KANJIRO (JP)
KIM HYUNJIN (JP)
TAKEMOTO HIROYASU (JP)
KATAOKA KAZUNORI (JP)
NISHIYAMA NOBUHIRO (JP)
ISHII ATSUSHI (JP)
KATO YASUKI (JP)
MIYATA KANJIRO (JP)
KIM HYUNJIN (JP)
TAKEMOTO HIROYASU (JP)
International Classes:
C08G81/00; C08L87/00; C08L89/00
Attorney, Agent or Firm:
Patent Profession Corporation Odajima Patent Office (9-15 Akasaka 1-chom, Minato-ku Tokyo 52, JP)
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Claims: