Title:
COPPER CATALYSIS-BASED METHOD FOR PREPARING CARBOXYLIC ACID COMPOUND BY MEANS OF ALCOHOL OXIDATION USING OXYGEN AS OXIDANT
Document Type and Number:
WIPO Patent Application WO/2022/206399
Kind Code:
A1
Abstract:
Disclosed in the present invention is a copper catalysis-based method for preparing a carboxylic acid compound by means of alcohol oxidation using oxygen as an oxidant. The method specifically comprises: in an organic solvent at a temperature of 25°C-50°C, using copper nitrate (Cu(NO3)2·3H2O), 2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) and an acidic inorganic salt as a catalyst, and using oxygen or air as an oxidant, generating a carboxylic acid compound by means of alcohol oxidation. The present invention has the advantages of simple operation, easy availability of raw materials and reagents, mild reaction conditions, high yield, wide compatibility of substrate functional groups, scalable reaction scale, environmental friendliness of the whole reaction process, no pollution, etc., and is a method suitable for industrialization.
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Inventors:
MA SHENGMING (CN)
YU YIBO (CN)
QIAN HUI (CN)
YU YIBO (CN)
QIAN HUI (CN)
Application Number:
PCT/CN2022/081399
Publication Date:
October 06, 2022
Filing Date:
March 17, 2022
Export Citation:
Assignee:
UNIV FUDAN (CN)
International Classes:
C07C51/235; C07C53/126; C07C53/19; C07C57/03; C07C57/18; C07C57/30; C07C59/125
Foreign References:
| CN112409144A | 2021-02-26 | |||
| CN101148400A | 2008-03-26 | |||
| CN112079706A | 2020-12-15 | |||
| CN107176899A | 2017-09-19 |
Other References:
JIANG XINGGUO, ZHANG JIASHENG, MA SHENGMING: "Iron Catalysis for Room-Temperature Aerobic Oxidation of Alcohols to Carboxylic Acids", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 138, no. 27, 13 July 2016 (2016-07-13), pages 8344 - 8347, XP055781772, ISSN: 0002-7863, DOI: 10.1021/jacs.6b03948
WAN YU ．, SHAN YU-HUA, SHI JUN, TIAN YUAN, ZHENG YI-TIAN, FENG YANG-YANG, LI MING-SHI, LU MO-HONG: "Base-free Catalytic Oxidation of 2-Ethylhexanol to 2-Ethylhexnoic Acid with Oxygen", FINE CHEMICALS, vol. 6, 1 June 2016 (2016-06-01), pages 654 - 659, XP055781768, DOI: 10.13550/j.jxhg.2016.06.009
WAN YU ．, SHAN YU-HUA, SHI JUN, TIAN YUAN, ZHENG YI-TIAN, FENG YANG-YANG, LI MING-SHI, LU MO-HONG: "Base-free Catalytic Oxidation of 2-Ethylhexanol to 2-Ethylhexnoic Acid with Oxygen", FINE CHEMICALS, vol. 6, 1 June 2016 (2016-06-01), pages 654 - 659, XP055781768, DOI: 10.13550/j.jxhg.2016.06.009
Attorney, Agent or Firm:
MSJLAW OFFICE (CN)
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