COPPER ORGANOCOMPLEXES, USE THEREOF AS ANTITUMOR MEANS AND FOR PROTECTING HEALTHY TISSUE FROM IONIZING RADIATION

Title:

COPPER ORGANOCOMPLEXES, USE THEREOF AS ANTITUMOR MEANS AND FOR PROTECTING HEALTHY TISSUE FROM IONIZING RADIATION

Document Type and Number:

WIPO Patent Application WO/2009/103807

Kind Code:

A8

Abstract:

The present invention relates to copper organocomplexes and pharmaceutical compositions comprised thereof. They can be used for the treatment of illnesses caused by hyperproliferative cells, and they also protect healthy tissue from ionizing radiation. They are prepared by reacting a copper(II) acylate having an acidic to neutral pH with an organic compound selected from 4-[bis(2-chloroethyl)-amino]-D,L-phenylalanine (Sarcolysin), the hydrochloride thereof, N-(2- furanidil)-5-fluoruracil (Tegafur) and aminocarbonylaziridin (Leacadin) in a chloroform/methanol mixture.

Inventors:

TATARSKIY VALERIY (DE)
PROKOP ARAM (DE)

Application Number:

PCT/EP2009/052073

Publication Date:

September 16, 2010

Filing Date:

February 20, 2009

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Assignee:

TATARSKIY VALERIY (DE)
CHARITE UNIVERSITAETSMEDIZIN (DE)
PROKOP ARAM (DE)

International Classes:

C07F1/00; A61K31/00; A61P35/00

Attorney, Agent or Firm:

GULDE HENGELHAUPT ZIEBIG & SCHNEIDER (Berlin, DE)

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