Title:
CORONAVIRUS DISEASE 2019 (COVID-19) RECOMBINANT SPIKE PROTEIN FORMING TRIMER, METHOD FOR MASS PRODUCING RECOMBINANT SPIKE PROTEIN IN PLANTS, AND METHOD FOR PREPARING VACCINE COMPOSITION ON BASIS THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/215857
Kind Code:
A1
Abstract:
The present invention relates to a coronavirus disease 2019 (COVID-19) recombinant spike protein forming a trimer, and a method for mass producing the recombinant spike protein in plants, and, specifically, to: a method for designing a recombinant gene, which expresses a coronavirus disease 2019 recombinant spike protein forming a trimer, in order to enhance immunogenicity and effectively deliver antigens; and a method for mass producing the recombinant spike protein in plants.
Inventors:
HWANG IN HWAN (KR)
SONG SHIJIAN (KR)
MD REZAUL ISLAM KHAN (KR)
HAIPING DIAO (KR)
SOHN EUN JU (KR)
CHOI BO HWA (KR)
CHOI JANG HOON (KR)
JANG EUN YOUNG (KR)
LEE YOUNG JAE (KR)
SONG SHIJIAN (KR)
MD REZAUL ISLAM KHAN (KR)
HAIPING DIAO (KR)
SOHN EUN JU (KR)
CHOI BO HWA (KR)
CHOI JANG HOON (KR)
JANG EUN YOUNG (KR)
LEE YOUNG JAE (KR)
Application Number:
PCT/KR2021/005124
Publication Date:
October 28, 2021
Filing Date:
April 22, 2021
Export Citation:
Assignee:
POSTECH ACAD IND FOUND (KR)
KOREA DISEASE CONTROL AND PREVENTION AGENCY (KR)
BIOAPPLICATIONS INC (KR)
KOREA DISEASE CONTROL AND PREVENTION AGENCY (KR)
BIOAPPLICATIONS INC (KR)
International Classes:
C12N15/82; C07K14/005
Foreign References:
| KR20160055164A | 2016-05-17 | |||
| KR20180058206A | 2018-05-31 | |||
| KR20170140180A | 2017-12-20 | |||
| KR20110034650A | 2011-04-05 | |||
| JP2018504119A | 2018-02-15 | |||
| KR20200048980A | 2020-05-08 | |||
| EP0120516B1 | 1991-10-23 | |||
| US4940838A | 1990-07-10 |
Other References:
SHOJI, YOKO ET AL.: "A plant-produced H1N1 trimeric hemagglutinin protects mice from a lethal influenza virus challenge", HUMAN VACCINES & IMMUNOTHERAPEUTICS, vol. 9, no. 3, March 2013 (2013-03-01), pages 553 - 560, XP055283062, DOI: 10.4161/hv.23234
HANAHAN, D., J. MOL. BIOL., vol. 166, 1983, pages 557 - 580
See also references of EP 4141120A4
HANAHAN, D., J. MOL. BIOL., vol. 166, 1983, pages 557 - 580
See also references of EP 4141120A4
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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