Title:
CORONAVIRUS INFECTION THERAPEUTIC AGENT FORMED THROUGH COMBINATION OF PYRAZINE DERIVATIVE AND ANOTHER CORONAVIRUS INFECTION THERAPEUTIC DRUG
Document Type and Number:
WIPO Patent Application WO/2021/221043
Kind Code:
A1
Abstract:
A coronavirus infection therapeutic agent comprising a combination of a pyrazine derivative or a salt thereof and another coronavirus infection therapeutic drug.
Inventors:
KOMENO TAKASHI (JP)
YAMASHITA NOZOMI (JP)
YAMASHITA NOZOMI (JP)
Application Number:
PCT/JP2021/016737
Publication Date:
November 04, 2021
Filing Date:
April 27, 2021
Export Citation:
Assignee:
FUJIFILM TOYAMA CHEMICAL CO LTD (JP)
International Classes:
A61K31/4965; A61K31/07; A61K31/11; A61K31/121; A61K31/122; A61K31/137; A61K31/138; A61K31/216; A61K31/343; A61K31/351; A61K31/352; A61K31/357; A61K31/366; A61K31/395; A61K31/403; A61K31/4045; A61K31/4178; A61K31/4184; A61K31/4245; A61K31/426; A61K31/427; A61K31/436; A61K31/439; A61K31/4706; A61K31/506; A61K31/517; A61K31/519; A61K31/522; A61K31/5365; A61K31/5377; A61K31/56; A61K31/573; A61K31/58; A61K31/59; A61K31/661; A61K31/662; A61K31/7056; A61K31/706; A61K31/716; A61K36/04; A61K36/19; A61K38/06; A61K38/12; A61K38/17; A61K38/21; A61K45/00; A61P31/14; A61P43/00
Domestic Patent References:
| WO2020138067A1 | 2020-07-02 | |||
| WO2000010569A1 | 2000-03-02 |
Foreign References:
| JP2016512833A | 2016-05-09 | |||
| JP2017524339A | 2017-08-31 | |||
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| JP2015525221A | 2015-09-03 | |||
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| JP2017178913A | 2017-10-05 |
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R VLASAK, T MUSTER, A M LAURO, J C POWERS, AND P PALESE: "Influenza C Virus Esterase: Analysis of Catalytic Site, Inhibition, and Possible Function", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 63, no. 5, 1 January 1989 (1989-01-01), US , pages 2056 - 2062, XP008156534, ISSN: 0022-538X
MATSUYAMA SHUTOKU, KAWASE MIYUKI, NAO NAGANORI, SHIRATO KAZUYA, UJIKE MAKOTO, KAMITANI WATARU, SHIMOJIMA MASAYUKI, FUKUSHI SHUETSU: "The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 95, no. 1, 9 December 2020 (2020-12-09), US , XP055868925, ISSN: 0022-538X, DOI: 10.1128/JVI.01648-20
L. M. JOHANSEN, BRANNAN J. M., DELOS S. E., SHOEMAKER C. J., STOSSEL A., LEAR C., HOFFSTROM B. G., DEWALD L. E., SCHORNBERG K. L.,: "FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection", SCIENCE TRANSLATIONAL MEDICINE, vol. 5, no. 190, 19 June 2013 (2013-06-19), pages 190ra79 - 190ra79, XP055230260, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.3005471
XIAOLING XU, HAN MINGFENG, LI TIANTIAN, SUN WEI, WANG DONGSHENG, FU BINQING, ZHOU YONGGANG, ZHENG XIAOHU, YANG YUN, LI XIUYONG, ZH: "Effective treatment of severe COVID-19 patients with tocilizumab", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 117, no. 20, 29 April 2020 (2020-04-29), pages 10970 - 10975, XP055740697, ISSN: 0027-8424, DOI: 10.1073/pnas.2005615117
WANG DONGYUAN; LI ZIGANG; LIU YIHUI: "An overview of the safety, clinical application and antiviral research of the COVID-19 therapeutics", JOURNAL OF INFECTION AND PUBLIC HEALTH, ELSEVIER, AMSTERDAM, NL, vol. 13, no. 10, 13 July 2020 (2020-07-13), AMSTERDAM, NL , pages 1405 - 1414, XP086276685, ISSN: 1876-0341, DOI: 10.1016/j.jiph.2020.07.004
JAMES M. SANDERS, MARGUERITE L. MONOGUE, TOMASZ Z. JODLOWSKI, JAMES B. CUTRELL: "Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19) : A Review", JAMA THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, AMERICAN MEDICAL ASSOCIATION, US, US , XP055695738, ISSN: 0098-7484, DOI: 10.1001/jama.2020.6019
YUTAKA HOSODA: "Senryou Kagaku", 1957, GIHODO CO., LTD., pages: 621
WANG CHORBY PWHAYDEN FGGAO GF: "A novel coronavirus outbreak of global health concern", LANCET, vol. 395, 2020, pages 470 - 3, XP086050316, DOI: 10.1016/S0140-6736(20)30185-9
CORONAVIRIDAE STUDY GROUP OF THE INTERNATIONAL COMMITTEE: "The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2", NAT MICROBIOL, 2 March 2020 (2020-03-02)
CORONAVIRUS DISEASE 2019 (COVID-19) SITUATION REPORTS, 22 March 2020 (2020-03-22)
ACS CENTRAL SCIENCE, vol. 6, no. 3, 2020, pages 315 - 331
W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2014, JOHN WILEY & SONS, INC, pages: 895 - 1193
WANG MCAO RZHANG LYANG XLIU JXU M ET AL.: "Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus [2019-nCoV] in vitro", CELL RES, vol. 30, 2020, pages 269 - 71, XP037049320, DOI: 10.1038/s41422-020-0282-0
KA-TIM CHOY, ALVINA YIN-LAM WONG, PRATHANPORN KAEWPREEDEE, SIN FUN SIA, DONGDONG CHEN, KENRIE PUI YAN HUI, DANIEL KA WING CHU, MIC: "Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 178, 1 June 2020 (2020-06-01), NL , pages 1 - 5, XP055738835, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2020.104786
BECK BO RAM, SHIN BONGGUN, CHOI YOONJUNG, PARK SUNGSOO, KANG KEUNSOO: "Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model", COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, RESEARCH NETWORK OF COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY, SWEDEN, vol. 18, 30 March 2020 (2020-03-30), Sweden , pages 784 - 790, XP055868923, ISSN: 2001-0370, DOI: 10.1016/j.csbj.2020.03.025
WILLIAMSON BRANDI N.; FELDMANN FRIEDERIKE; SCHWARZ BENJAMIN; MEADE-WHITE KIMBERLY; PORTER DANIELLE P.; SCHULZ JONATHAN; VAN DOREMA: "Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 585, no. 7824, 9 June 2020 (2020-06-09), London, pages 273 - 276, XP037241501, ISSN: 0028-0836, DOI: 10.1038/s41586-020-2423-5
WANG MANLI; CAO RUIYUAN; ZHANG LEIKE; YANG XINGLOU; LIU JIA; XU MINGYUE; SHI ZHENGLI; HU ZHIHONG; ZHONG WU; XIAO GENGFU: "Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro", CELL RESEARCH, SPRINGER SINGAPORE, SINGAPORE, vol. 30, no. 3, 4 February 2020 (2020-02-04), Singapore , pages 269 - 271, XP037049320, ISSN: 1001-0602, DOI: 10.1038/s41422-020-0282-0
GREIN JONATHAN: "Compassionate Use of Remdesivir for Patients with Severe Covid-19", THE NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 382, no. 24, 11 June 2020 (2020-06-11), US , pages 2327 - 2336, XP055832045, ISSN: 0028-4793, DOI: 10.1056/NEJMoa2007016
R VLASAK, T MUSTER, A M LAURO, J C POWERS, AND P PALESE: "Influenza C Virus Esterase: Analysis of Catalytic Site, Inhibition, and Possible Function", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 63, no. 5, 1 January 1989 (1989-01-01), US , pages 2056 - 2062, XP008156534, ISSN: 0022-538X
MATSUYAMA SHUTOKU, KAWASE MIYUKI, NAO NAGANORI, SHIRATO KAZUYA, UJIKE MAKOTO, KAMITANI WATARU, SHIMOJIMA MASAYUKI, FUKUSHI SHUETSU: "The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 95, no. 1, 9 December 2020 (2020-12-09), US , XP055868925, ISSN: 0022-538X, DOI: 10.1128/JVI.01648-20
L. M. JOHANSEN, BRANNAN J. M., DELOS S. E., SHOEMAKER C. J., STOSSEL A., LEAR C., HOFFSTROM B. G., DEWALD L. E., SCHORNBERG K. L.,: "FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection", SCIENCE TRANSLATIONAL MEDICINE, vol. 5, no. 190, 19 June 2013 (2013-06-19), pages 190ra79 - 190ra79, XP055230260, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.3005471
XIAOLING XU, HAN MINGFENG, LI TIANTIAN, SUN WEI, WANG DONGSHENG, FU BINQING, ZHOU YONGGANG, ZHENG XIAOHU, YANG YUN, LI XIUYONG, ZH: "Effective treatment of severe COVID-19 patients with tocilizumab", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 117, no. 20, 29 April 2020 (2020-04-29), pages 10970 - 10975, XP055740697, ISSN: 0027-8424, DOI: 10.1073/pnas.2005615117
WANG DONGYUAN; LI ZIGANG; LIU YIHUI: "An overview of the safety, clinical application and antiviral research of the COVID-19 therapeutics", JOURNAL OF INFECTION AND PUBLIC HEALTH, ELSEVIER, AMSTERDAM, NL, vol. 13, no. 10, 13 July 2020 (2020-07-13), AMSTERDAM, NL , pages 1405 - 1414, XP086276685, ISSN: 1876-0341, DOI: 10.1016/j.jiph.2020.07.004
JAMES M. SANDERS, MARGUERITE L. MONOGUE, TOMASZ Z. JODLOWSKI, JAMES B. CUTRELL: "Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19) : A Review", JAMA THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, AMERICAN MEDICAL ASSOCIATION, US, US , XP055695738, ISSN: 0098-7484, DOI: 10.1001/jama.2020.6019
YUTAKA HOSODA: "Senryou Kagaku", 1957, GIHODO CO., LTD., pages: 621
WANG CHORBY PWHAYDEN FGGAO GF: "A novel coronavirus outbreak of global health concern", LANCET, vol. 395, 2020, pages 470 - 3, XP086050316, DOI: 10.1016/S0140-6736(20)30185-9
CORONAVIRIDAE STUDY GROUP OF THE INTERNATIONAL COMMITTEE: "The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2", NAT MICROBIOL, 2 March 2020 (2020-03-02)
CORONAVIRUS DISEASE 2019 (COVID-19) SITUATION REPORTS, 22 March 2020 (2020-03-22)
ACS CENTRAL SCIENCE, vol. 6, no. 3, 2020, pages 315 - 331
W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2014, JOHN WILEY & SONS, INC, pages: 895 - 1193
WANG MCAO RZHANG LYANG XLIU JXU M ET AL.: "Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus [2019-nCoV] in vitro", CELL RES, vol. 30, 2020, pages 269 - 71, XP037049320, DOI: 10.1038/s41422-020-0282-0
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ASAMURA PATENT OFFICE, P.C. (JP)
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