Title:
CORONAVIRUS VACCINE
Document Type and Number:
WIPO Patent Application WO/2022/020545
Kind Code:
A3
Abstract:
The present invention includes and immunogenic composition and methods of immunizing a mammal or avian comprising: a nanoparticle conjugated to one or more antigenic peptides or fusion polypeptides from more than one strain of virus, wherein the one or more antigenic peptides or fusion polypeptides elicit at least one of a humoral, T helper cell-1 (Th1), T helper cell-2 (Th2) or cytotoxic T cell (CTL) immune response. In certain embodiments the antigenic peptides or fusion polypeptides are selected from at least one of SEQ IN NOS: 1 to 16, 22 to 39, or any combination thereof.
Inventors:
GILL HARVINDER (US)
JOSHI GAURAV (US)
JOSHI GAURAV (US)
Application Number:
PCT/US2021/042692
Publication Date:
March 10, 2022
Filing Date:
July 22, 2021
Export Citation:
Assignee:
UNIV TEXAS TECH SYSTEM (US)
International Classes:
A61K39/215; A61K39/12; A61P31/14; C12N7/01; C12N15/63
Domestic Patent References:
| WO2018075980A1 | 2018-04-26 | |||
| WO2004080403A2 | 2004-09-23 | |||
| WO2016168817A1 | 2016-10-20 |
Foreign References:
| US20060134753A1 | 2006-06-22 | |||
| US20100158939A1 | 2010-06-24 | |||
| US20100055189A1 | 2010-03-04 |
Other References:
CAVANAGH, D ET AL.: "Coronavirus IBV: partial amino terminal sequencing of spike polypeptide S2 identifies the sequence Arg-Arg-Phe-Arg-Arg at the cleavage site of the spike precursor propolypeptide of IBV strains Beaudette and M41", VIRUS RESEARCH, vol. 4, no. 2, February 1986 (1986-02-01), pages 133 - 143, XP023706741, DOI: 10.1016/0168-1702(86)90037-7
MOTOKAWA ET AL.: "Comparison of the Amino Acid Sequence and Phylogenetic Analysis of the Peplomer, Integral Membrane and Nucleocapsid Proteins of Feline, Canine and Porcine Coronaviruses", MICROBIOLOGY AND IMMUNOLOGY, vol. 40, no. 6, 1996, pages 425 - 433, XP002109383, DOI: 10.1111/j.1348-0421.1996.tb01089.x
MOTOKAWA ET AL.: "Comparison of the Amino Acid Sequence and Phylogenetic Analysis of the Peplomer, Integral Membrane and Nucleocapsid Proteins of Feline, Canine and Porcine Coronaviruses", MICROBIOLOGY AND IMMUNOLOGY, vol. 40, no. 6, 1996, pages 425 - 433, XP002109383, DOI: 10.1111/j.1348-0421.1996.tb01089.x
Attorney, Agent or Firm:
CHALKER, Daniel, J. et al. (US)
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