Title:
CORRELATION OF DISEASE ACTIVITY WITH CLONAL EXPANSIONS OF HUMAN PAPILLOMAVIRUS 16-SPECIFIC CD8+ T-CELLS IN PATIENTS WITH SEVERE EROSIVE ORAL LICHEN PLANUS
Document Type and Number:
WIPO Patent Application WO/2015/018943
Kind Code:
A3
Abstract:
A massive clonal expansion of activated CD8+ T-cells with increased frequency of HPV 16- specific CD8+ T-cells was discovered to be a characteristic of oral lichen planus (OLP), indicating a causal link between HPV infection and the dysimmune process. The invention relates to compositions and methods for the diagnosis and treatment of OLP patients.
Inventors:
GOUGEON MARIE-LISE (FR)
VIGUIER MANUELLE (FR)
BACHELEZ HERVÉ (FR)
FAZILLEAU NICOLAS (FR)
VIGUIER MANUELLE (FR)
BACHELEZ HERVÉ (FR)
FAZILLEAU NICOLAS (FR)
Application Number:
PCT/EP2014/067131
Publication Date:
June 11, 2015
Filing Date:
August 08, 2014
Export Citation:
Assignee:
PASTEUR INSTITUT (FR)
INST NAT SANTE RECH MED (FR)
UNIV PARIS DIDEROT PARIS 7 (FR)
ASSIST PUBL HOPITAUX DE PARIS (FR)
INST NAT SANTE RECH MED (FR)
UNIV PARIS DIDEROT PARIS 7 (FR)
ASSIST PUBL HOPITAUX DE PARIS (FR)
International Classes:
G01N33/50
Domestic Patent References:
| WO2005089792A1 | 2005-09-29 | |||
| WO2008147187A1 | 2008-12-04 | |||
| WO2008116078A2 | 2008-09-25 | |||
| WO2003093496A1 | 2003-11-13 |
Other References:
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; September 2005 (2005-09-01), VIGUIER M ET AL: "Effector and regulatory T cell populations in patients treated with extracorporeal photochemotherapy for severe erosive Lichen planus", XP002732410, Database accession no. PREV200600059533
COX M ET AL: "Human herpes simplex-1 and papillomavirus type 16 homologous DNA sequences in normal, potentially malignant and malignant oral mucosa", EUROPEAN JOURNAL OF CANCER. PART B, ORAL ONCOLOGY, PERGAMON, OXFORD, GB, vol. 29, no. 3, 1 January 1993 (1993-01-01), pages 215 - 219, XP026246301, ISSN: 0964-1955, [retrieved on 19930101], DOI: 10.1016/0964-1955(93)90025-A
CAMPISI G ET AL: "HPV DNA in clinically different variants of oral leukoplakia and lichen planus", ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY AND ENDODONTICS, MOSBY-YEAR BOOK, ST. LOUIS, MO, US, vol. 98, no. 6, 1 December 2004 (2004-12-01), pages 705 - 711, XP004666917, ISSN: 1079-2104, DOI: 10.1016/J.TRIPLEO.2004.04.012
LODI G ET AL: "Current controversies in oral lichen planus: Report of an international consensus meeting. Part 2. Clinical management and malignant transformation", ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY AND ENDODONTICS, MOSBY-YEAR BOOK, ST. LOUIS, MO, US, vol. 100, no. 2, 1 August 2005 (2005-08-01), pages 164 - 178, XP004986679, ISSN: 1079-2104, DOI: 10.1016/J.TRIPLEO.2004.06.076
LODI G ET AL: "Current controversies in oral lichen planus: Report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis", ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY AND ENDODONTICS, MOSBY-YEAR BOOK, ST. LOUIS, MO, US, vol. 100, no. 1, 1 July 2005 (2005-07-01), pages 40 - 51, XP004937924, ISSN: 1079-2104, DOI: 10.1016/J.TRIPLEO.2004.06.077
FARHI D ET AL: "Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: facts and controversies", CLINICS IN DERMATOLOGY, J.B. LIPPINCOTT, PHILADELPHIA, PA, US, vol. 28, no. 1, 1 January 2010 (2010-01-01), pages 100 - 108, XP027279006, ISSN: 0738-081X, [retrieved on 20091215]
BENAY TOKMAN, BURCU SENGUVEN: "PP4-179 - PREVALANCE OF EBV, HPV 16 AND HSV-1 IN ORAL LICHEN PLANUS", VIRCHOWS ARCHIV, SPRINGER, BERLIN, DE, vol. 451, no. 2, 15 August 2007 (2007-08-15), pages 549 - 549, XP019542474, ISSN: 1432-2307, DOI: 10.1007/S00428-007-0493-5
MANUELLE VIGUIER ET AL: "Peripheral and Local Human Papillomavirus 16-Specific CD8+ T-Cell Expansions Characterize Erosive Oral Lichen Planus", JOURNAL OF INVESTIGATIVE DERMATOLOGY, 10 September 2014 (2014-09-10), XP055151760, ISSN: 0022-202X, DOI: 10.1038/jid.2014.397
COX M ET AL: "Human herpes simplex-1 and papillomavirus type 16 homologous DNA sequences in normal, potentially malignant and malignant oral mucosa", EUROPEAN JOURNAL OF CANCER. PART B, ORAL ONCOLOGY, PERGAMON, OXFORD, GB, vol. 29, no. 3, 1 January 1993 (1993-01-01), pages 215 - 219, XP026246301, ISSN: 0964-1955, [retrieved on 19930101], DOI: 10.1016/0964-1955(93)90025-A
CAMPISI G ET AL: "HPV DNA in clinically different variants of oral leukoplakia and lichen planus", ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY AND ENDODONTICS, MOSBY-YEAR BOOK, ST. LOUIS, MO, US, vol. 98, no. 6, 1 December 2004 (2004-12-01), pages 705 - 711, XP004666917, ISSN: 1079-2104, DOI: 10.1016/J.TRIPLEO.2004.04.012
LODI G ET AL: "Current controversies in oral lichen planus: Report of an international consensus meeting. Part 2. Clinical management and malignant transformation", ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY AND ENDODONTICS, MOSBY-YEAR BOOK, ST. LOUIS, MO, US, vol. 100, no. 2, 1 August 2005 (2005-08-01), pages 164 - 178, XP004986679, ISSN: 1079-2104, DOI: 10.1016/J.TRIPLEO.2004.06.076
LODI G ET AL: "Current controversies in oral lichen planus: Report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis", ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY AND ENDODONTICS, MOSBY-YEAR BOOK, ST. LOUIS, MO, US, vol. 100, no. 1, 1 July 2005 (2005-07-01), pages 40 - 51, XP004937924, ISSN: 1079-2104, DOI: 10.1016/J.TRIPLEO.2004.06.077
FARHI D ET AL: "Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: facts and controversies", CLINICS IN DERMATOLOGY, J.B. LIPPINCOTT, PHILADELPHIA, PA, US, vol. 28, no. 1, 1 January 2010 (2010-01-01), pages 100 - 108, XP027279006, ISSN: 0738-081X, [retrieved on 20091215]
BENAY TOKMAN, BURCU SENGUVEN: "PP4-179 - PREVALANCE OF EBV, HPV 16 AND HSV-1 IN ORAL LICHEN PLANUS", VIRCHOWS ARCHIV, SPRINGER, BERLIN, DE, vol. 451, no. 2, 15 August 2007 (2007-08-15), pages 549 - 549, XP019542474, ISSN: 1432-2307, DOI: 10.1007/S00428-007-0493-5
MANUELLE VIGUIER ET AL: "Peripheral and Local Human Papillomavirus 16-Specific CD8+ T-Cell Expansions Characterize Erosive Oral Lichen Planus", JOURNAL OF INVESTIGATIVE DERMATOLOGY, 10 September 2014 (2014-09-10), XP055151760, ISSN: 0022-202X, DOI: 10.1038/jid.2014.397
Attorney, Agent or Firm:
REGIMBEAU (Paris Cedex 17, Paris Cedex 17, FR)
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