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Title:
COUMARIN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2014/046224
Kind Code:
A1
Abstract:
The purpose of the invention is to provide a novel coumarin derivative or pharmaceutically acceptable salt thereof and a drug containing this compound as an active ingredient. This coumarin derivative or pharmaceutically acceptable salt thereof presents an excellent cartilage destruction-inhibiting effect and synovial cell proliferation-inhibiting effect in pharmacological studies taking release of sulfated glycosaminoglycans (sGAG) and proliferation of synovial cells as indicators, and therefore is extremely useful as an active ingredient of pharmaceutical compositions for the prevention or treatment of osteoarthritis, rheumatoid arthritis, and other such arthropathies. (In the formula R1 and R2 are the same or different, (a) alkoxy, alkyl, cyano, nitro, hydroxy, trifluoromethyl, amino, carboxy, alkoxycarbonyl, phenyl, or phenyl optionally substituted by one or two halogens, (b) pyridyl, (c) alkyl, or (d) thienyl.)

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Inventors:
NAIKI MITSURU (JP)
OKADA TOMOYUKI (JP)
SAWADA KAZUYOSHI (JP)
OGINO TAKASHI (JP)
Application Number:
PCT/JP2013/075414
Publication Date:
March 27, 2014
Filing Date:
September 20, 2013
Export Citation:
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Assignee:
NIPPON ZOKI PHARMACEUTICAL CO (JP)
International Classes:
C07D311/18; A61K31/352; A61K31/381; A61K31/4406; A61P19/02; A61P29/00; C07D405/12; C07D409/12
Domestic Patent References:
WO2009014100A12009-01-29
WO1994023714A11994-10-27
Foreign References:
JP2008505064A2008-02-21
JPH1067772A1998-03-10
Other References:
PATONAY, T. ET AL.: "Synthesis, antibacterial and antifungal activity of 4-hydroxycoumarin derivatives, analogs of novobiocin", PHARMAZIE, vol. 39, no. 2, 1 January 1984 (1984-01-01), pages 86 - 91, XP001526727
SCIENCE AND CULTURE, vol. 31, no. 1, 1965, pages 27
SCIENCE AND CULTURE, vol. 37, no. 1, 1971, pages 58 - 59
See also references of EP 2899187A4
Attorney, Agent or Firm:
FUJII, Ikuro (JP)
Fujii Ikuro (JP)
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