COUMARIN DERIVATIVES USEFUL AS TNF alpha INHIBITORS

WIPO Patent Application WO2002008217

A3

Novel compounds composition capable of inhibiting TNF alpha and having antiimmunoinflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.

CHENG JIE FEI (US)
ARRHENIUS THOMAS (US)
WALLACE DAVID (US)
CHEN MI (US)
TITH SOVOUTHY (US)
KASHIWAGI HIROTAKA (JP)
ONO YOSHIYUKI (JP)
WATANABE YOSHIAKI (JP)

PCT/US2001/022950

April 18, 2002

July 19, 2001

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CHUGAI PHARMACEUTICAL CO LTD (JP)
CHENG JIE FEI (US)
ARRHENIUS THOMAS (US)
WALLACE DAVID (US)
CHEN MI (US)
TITH SOVOUTHY (US)
KASHIWAGI HIROTAKA (JP)
ONO YOSHIYUKI (JP)
WATANABE YOSHIAKI (JP)

A61K31/37; A61K31/381; A61K31/4025; A61K31/4178; A61K31/4184; A61K31/422; A61K31/427; A61K31/4433; A61K31/453; A61K31/496; A61K31/506; A61K31/5377; A61K31/541; A61K31/7048; A61P1/04; A61P3/10; A61P7/00; A61P9/10; A61P11/02; A61P11/06; A61P11/16; A61P17/06; A61P19/02; A61P19/08; A61P19/10; A61P21/00; A61P25/00; A61P25/18; A61P27/02; A61P29/00; A61P29/02; A61P31/04; A61P33/06; A61P35/00; A61P37/02; A61P37/06; A61P39/02; A61P43/00; C07D311/16; C07D311/18; C07D405/04; C07D405/06; C07D405/12; C07D405/14; C07D407/06; C07D409/06; C07D417/06; C07D417/12; (IPC1-7): C07D311/16; A61K31/35; A61P29/00; C07D405/04; C07D405/06; C07D405/12; C07D405/14

WO1999015523A1

1999-04-01

CH522631A	1972-06-30
EP0171645A1	1986-02-19
EP0428939A2	1991-05-29

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