Title:
COVALENT APTAMERS
Document Type and Number:
WIPO Patent Application WO/2022/232195
Kind Code:
A3
Abstract:
Disclosed are chemically modified aptamers comprising an electrophilic group and a handle and methods for using said aptamers to deliver the handle to a target protein, crosslink the aptamer to the target protein, as well as methods of using said aptamers to detect proteins and to treat viral infections or cancer.
Inventors:
DEITERS ALEXANDER (US)
TIVON YANIV (US)
CACACE MARY (US)
ALBRIGHT SAVANNAH (US)
TIVON YANIV (US)
CACACE MARY (US)
ALBRIGHT SAVANNAH (US)
Application Number:
PCT/US2022/026414
Publication Date:
January 05, 2023
Filing Date:
April 26, 2022
Export Citation:
Assignee:
UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION (US)
International Classes:
C12N15/115; G01N21/63; G01N21/64; G01N33/542
Foreign References:
| US20190054156A1 | 2019-02-21 |
Other References:
LI YANG, YIMING ZHOU, XIULI YUE, ZHIFEI DAI: "Cyanine Conjugate-Based Biomedical Imaging Probes", ADVANCED HEALTHCARE MATERIALS, vol. 9, no. 22, 1 October 2020 (2020-10-01), pages 2001327, XP093022001, DOI: 10.1002/adhm.202001327
MUSUMECI, D ET AL.: "Fluorescence Sensing Using DNA Aptamers in Cancer Research and Clinical Diagnostics", CANCERS, vol. 9, no. 12, 20 December 2017 (2017-12-20), pages 1 - 43, XP055533646, DOI: 10.3390/cancers9120174
WANG, C ET AL.: "A sensitive thrombin-linked sandwich immunoassay for protein targets using high affinity phosphorodithioate modified aptamer for thrombin labeling", TALANTA, vol. 207, 19 August 2019 (2019-08-19), pages 1 - 6, XP085851646, DOI: 10.1016fj.talanta.2019.120280
MUSUMECI, D ET AL.: "Fluorescence Sensing Using DNA Aptamers in Cancer Research and Clinical Diagnostics", CANCERS, vol. 9, no. 12, 20 December 2017 (2017-12-20), pages 1 - 43, XP055533646, DOI: 10.3390/cancers9120174
WANG, C ET AL.: "A sensitive thrombin-linked sandwich immunoassay for protein targets using high affinity phosphorodithioate modified aptamer for thrombin labeling", TALANTA, vol. 207, 19 August 2019 (2019-08-19), pages 1 - 6, XP085851646, DOI: 10.1016fj.talanta.2019.120280
Attorney, Agent or Firm:
LANIER, J. Gibson (US)
Download PDF:
Previous Patent: LIPID NANOMATERIALS AND USES THEREOF
Next Patent: LOW POWER ANALOG CIRCUITRY FOR ARTIFICIAL NEURAL NETWORKS
Next Patent: LOW POWER ANALOG CIRCUITRY FOR ARTIFICIAL NEURAL NETWORKS