Title:
G9A/GLP COVALENT INHIBITOR AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/000763
Kind Code:
A1
Abstract:
Provided are a G9a/GLP covalent inhibitor and a preparation method therefor and a use thereof. The G9a/GLP covalent inhibitor is a compound having a structure as shown in formula (I) and a salt thereof:
Inventors:
WANG YUANXIANG (CN)
WANG JUNJIAN (CN)
FENG ZONGBO (CN)
YANG CHUNJU (CN)
LIU PEIQING (CN)
WANG JUNJIAN (CN)
FENG ZONGBO (CN)
YANG CHUNJU (CN)
LIU PEIQING (CN)
Application Number:
PCT/CN2022/113518
Publication Date:
January 04, 2024
Filing Date:
August 19, 2022
Export Citation:
Assignee:
UNIV SUN YAT SEN (CN)
GUANGZHOU SYSU NANSHA SCIENCE & TECH INNOVATION PARK CO LTD (CN)
GUANGZHOU SYSU NANSHA SCIENCE & TECH INNOVATION PARK CO LTD (CN)
International Classes:
C07D401/12; A61K31/4709; A61K31/498; A61P35/00; C07D401/14
Foreign References:
| US20200010454A1 | 2020-01-09 | |||
| CN106536509A | 2017-03-22 | |||
| CN113248481A | 2021-08-13 |
Other References:
CAO, HAO ET AL.: "“Recent Progress in Histone Methyltransferase (G9a) Inhibitors as Anticancer Agents”", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 179, 28 June 2019 (2019-06-28), pages 537 - 546, XP085772612, DOI: 10.1016/j.ejmech.2019.06.072
LIU, FENG ET AL.: "“Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines"", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, 22 July 2011 (2011-07-22), pages 6139 - 6150, XP002702500, DOI: 10.1021/jm200903z
LIU, FENG ET AL.: "“Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines"", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, 22 July 2011 (2011-07-22), pages 6139 - 6150, XP002702500, DOI: 10.1021/jm200903z
Attorney, Agent or Firm:
YOGO PATENT AND TRADEMARK AGENCY LIMITED COMPANY (CN)
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