Title:
CP-IRGD POLYPEPTIDE, IDPP NANOPARTICLE, DRUG-LOADING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/137658
Kind Code:
A1
Abstract:
The present invention relates to the technical field of medicines and provides a CP-iRGD polypeptide, an iRGD-DOTAP-mPEG-PLA nanoparticle, a drug-loading compound, a preparation method therefor and uses thereof. In the present invention, an amphiphilic mPEG-PLA diblock copolymer is modified by using a positively charged amphiphilic substance DOTAP and a modified CP-iRGD polypeptide having a tumor targeting effect, and a self-assembling method is used to prepare the iRGD-DOTAP-mPEG-PLA nanoparticle of a degradable gene vector, i.e., the iDPP nanoparticle. The nanoparticle can introduce gene plasmids into tumor cells.
Inventors:
GOU MALING (CN)
WEI YUQUAN (CN)
LUO LI (CN)
YANG YUPING (CN)
CHEN YUWEN (CN)
WEI YUQUAN (CN)
LUO LI (CN)
YANG YUPING (CN)
CHEN YUWEN (CN)
Application Number:
PCT/CN2018/073997
Publication Date:
August 02, 2018
Filing Date:
January 24, 2018
Export Citation:
Assignee:
SI CHUAN UNIV (CN)
International Classes:
C07K7/06; A61K47/34; A61K47/54; A61K47/62; A61K47/69; A61K48/00; A61P35/00; A61P35/04; C07K1/06; C07K1/113
Domestic Patent References:
| WO2016191556A1 | 2016-12-01 | |||
| WO2016054315A1 | 2016-04-07 |
Foreign References:
| CN105362251A | 2016-03-02 | |||
| CN106265598A | 2017-01-04 | |||
| CN104546728A | 2015-04-29 | |||
| CN104159572A | 2014-11-19 | |||
| CN105646649A | 2016-06-08 |
Attorney, Agent or Firm:
CHENGDU HONGQIAO PATENT LAW OFFICE (CN)
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