Title:
CpG SPACER-OLIGONUCLEOTIDE-CONTAINING COMPLEX HAVING IMMUNOPOTENTIATING ACTIVITY, AND USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2016/152767
Kind Code:
A1
Abstract:
The present invention provides an oligodeoxynucleotide containing humanized K-type CpG oligodeoxynucleotide and polydeoxyadenylic acid, wherein the polydeoxyadenylic acid is located on the 3' side of the humanized K-type CpG oligodeoxynucleotide with a spacer interposed therebetween. The present invention also provides a complex containing this oligodeoxynucleotide and β-1,3-glucan.
Inventors:
KOIZUMI MAKOTO (JP)
NIWA TAKAKO (JP)
JONAI NAO (JP)
ISHII KEN (JP)
KOBIYAMA KOUJI (JP)
NIWA TAKAKO (JP)
JONAI NAO (JP)
ISHII KEN (JP)
KOBIYAMA KOUJI (JP)
Application Number:
PCT/JP2016/058668
Publication Date:
September 29, 2016
Filing Date:
March 18, 2016
Export Citation:
Assignee:
NAT INST OF BIOMEDICAL INNOVATION HEALTH AND NUTRITION (JP)
DAIICHI SANKYO CO LTD (JP)
DAIICHI SANKYO CO LTD (JP)
International Classes:
C12N15/117; A61K31/7125; A61K39/00; A61K39/145; A61K39/155; A61K45/00; A61P31/04; A61P31/12; A61P31/16; A61P33/00; A61P35/00; A61P37/04; A61P37/08; C12N15/09
Domestic Patent References:
| WO2015041318A1 | 2015-03-26 |
Foreign References:
| JP2010507386A | 2010-03-11 | |||
| JP2009035530A | 2009-02-19 | |||
| JP2010504982A | 2010-02-18 | |||
| US20080152662A1 | 2008-06-26 | |||
| JP2005518402A | 2005-06-23 | |||
| JP2010174107A | 2010-08-12 |
Other References:
LIU Q ET AL., JOURNAL OF MATERIALS CHEMISTRY B, vol. 2, no. 8, 2014, pages 933 - 944, XP055317844
KOBIYAMA K ET AL.: "Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist.", PROC. NATL. ACAD. SCI. USA, vol. 111, no. 8, 2014, pages 3086 - 3091, XP055317846
MINARI J ET AL.: "Enhanced cytokine secretion from primary macrophages due to Dectin-1 mediated uptake of CpG DNA/(3-1,3-glucan complex.", BIOCONJUG. CHEM., vol. 22, no. 1, 2011, pages 9 - 15, XP055317850
CHEN N ET AL.: "Self-asembly of poly-adenine- tailed CpG oligonucleotide-gold nanoparticle nanoconjugates with immunostimulatory activity", SMALL, vol. 10, no. 2, 2014, pages 368 - 375, XP055141674
MARSHALL JD ET AL.: "Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells", NUCLEIC ACIDS RES., vol. 31, no. 17, 2003, pages 5122 - 5133, XP003007082
DONG Y ET AL.: "Design, synthesis, and immunostimulatory properties of CpG DNAs containing alkyl-linker substitutions: role of nucleosides in the flanking sequences", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 20, 2002, pages 4540 - 4548, XP002478300
HIROKO MIYAMOTO ET AL.: "Selective Delivery of Oligonucletide Using a BETA-1,3-glucan Receptor", CELLULOSE COMMUN., vol. 19, no. 1, 2012, pages 12 - 16
OBA K ET AL.: "Individual patient based meta- analysis of lentinan for unresectable/recurrent gastric cancer", ANTICANCER RES., vol. 29, no. 7, 2009, pages 2739 - 2745, XP055317857
DURAND M ET AL.: "Triple-helix formation by an oligonucleotide containing one (dA)12 and two (dT)12 sequences bridged by two hexaethylene glycol chains", BIOCHEMISTRY, vol. 31, no. 38, 1992, pages 9197 - 9204, XP002329296
SHIN'ICHI MOCHIZUKI ET AL.: "CpG-DNA/P-1,3- glucan Fukugotai no Shinki Gan Vaccine eno Oyo", POLYMER PREPRINTS, JAPAN, vol. 62, no. 2, 2013, pages 4825 - 4826
KOBIYAMA K ET AL.: "Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist.", PROC. NATL. ACAD. SCI. USA, vol. 111, no. 8, 2014, pages 3086 - 3091, XP055317846
MINARI J ET AL.: "Enhanced cytokine secretion from primary macrophages due to Dectin-1 mediated uptake of CpG DNA/(3-1,3-glucan complex.", BIOCONJUG. CHEM., vol. 22, no. 1, 2011, pages 9 - 15, XP055317850
CHEN N ET AL.: "Self-asembly of poly-adenine- tailed CpG oligonucleotide-gold nanoparticle nanoconjugates with immunostimulatory activity", SMALL, vol. 10, no. 2, 2014, pages 368 - 375, XP055141674
MARSHALL JD ET AL.: "Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells", NUCLEIC ACIDS RES., vol. 31, no. 17, 2003, pages 5122 - 5133, XP003007082
DONG Y ET AL.: "Design, synthesis, and immunostimulatory properties of CpG DNAs containing alkyl-linker substitutions: role of nucleosides in the flanking sequences", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 20, 2002, pages 4540 - 4548, XP002478300
HIROKO MIYAMOTO ET AL.: "Selective Delivery of Oligonucletide Using a BETA-1,3-glucan Receptor", CELLULOSE COMMUN., vol. 19, no. 1, 2012, pages 12 - 16
OBA K ET AL.: "Individual patient based meta- analysis of lentinan for unresectable/recurrent gastric cancer", ANTICANCER RES., vol. 29, no. 7, 2009, pages 2739 - 2745, XP055317857
DURAND M ET AL.: "Triple-helix formation by an oligonucleotide containing one (dA)12 and two (dT)12 sequences bridged by two hexaethylene glycol chains", BIOCHEMISTRY, vol. 31, no. 38, 1992, pages 9197 - 9204, XP002329296
SHIN'ICHI MOCHIZUKI ET AL.: "CpG-DNA/P-1,3- glucan Fukugotai no Shinki Gan Vaccine eno Oyo", POLYMER PREPRINTS, JAPAN, vol. 62, no. 2, 2013, pages 4825 - 4826
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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