Title:
CRANIAL NERVE MODELING DEVICE
Document Type and Number:
WIPO Patent Application WO/2023/146249
Kind Code:
A1
Abstract:
A cranial nerve modeling device for mimicking a brain micro-environment, according to one embodiment, is disclosed. The cranial nerve modeling device comprises: a microfluidic chip including a plurality of cell culture channels, and electrodes for applying electrical stimulation signals to at least one of the cell culture channels or measuring activation signals of nerve cells cultured in the cell culture channels; a control unit for determining the electrical stimulation signals to be provided through the electrodes, and processing the measured activation signals; and a micro-pump for providing a culture medium to the cell culture channels, wherein the cell culture channels can include a first cerebrovascular barrier mimicking channel, a neuroglial cell channel, a first nerve cell channel, an axon guidance channel, a second nerve cell channel and a second cerebrovascular barrier-mimicking channel.
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Inventors:
CHOI HYUK (KR)
LEE JAE-WON (KR)
YOON WON KI (KR)
HWANG MIN HO (KR)
LEE JAE-WON (KR)
YOON WON KI (KR)
HWANG MIN HO (KR)
Application Number:
PCT/KR2023/001097
Publication Date:
August 03, 2023
Filing Date:
January 25, 2023
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C12M1/42; C12M1/12; C12M1/34; C12M3/00; C12M3/06; C12N5/0793
Domestic Patent References:
| WO2021077064A1 | 2021-04-22 |
Foreign References:
| KR20180080670A | 2018-07-12 | |||
| US9261496B2 | 2016-02-16 |
Other References:
DE JONGH RIANNE, SPIJKERS XANDOR M., PASTEUNING‐VUHMAN SVETLANA, VULTO PAUL, PASTERKAMP R. JEROEN: "Neuromuscular junction‐on‐a‐chip: ALS disease modeling and read‐out development in microfluidic devices", JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 157, no. 3, 1 May 2021 (2021-05-01), GB , pages 393 - 412, XP093081914, ISSN: 0022-3042, DOI: 10.1111/jnc.15289
AHN SONG IH, SEI YOSHITAKA J., PARK HYUN-JI, KIM JINHWAN, RYU YUJUNG, CHOI JEONGMOON J., SUNG HAK-JOON, MACDONALD TOBEY J., LEVEY : "Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms", NATURE COMMUNICATIONS, vol. 11, no. 1, XP093081916, DOI: 10.1038/s41467-019-13896-7
WAN JIANDI, ZHOU SITONG, MEA HING JII, GUO YAOJUN, KU HANSOL, URBINA BRIANNA M.: "Emerging Roles of Microfluidics in Brain Research: From Cerebral Fluids Manipulation to Brain-on-a-Chip and Neuroelectronic Devices Engineering", CHEMICAL REVIEWS, AMERICAN CHEMICAL SOCIETY, US, vol. 122, no. 7, 13 April 2022 (2022-04-13), US , pages 7142 - 7181, XP093081920, ISSN: 0009-2665, DOI: 10.1021/acs.chemrev.1c00480
VYSOKOV NICKOLAI, MCMAHON STEPHEN B., RAOUF RAMIN: "The role of NaV channels in synaptic transmission after axotomy in a microfluidic culture platform", SCIENTIFIC REPORTS, vol. 9, no. 1, XP093081928, DOI: 10.1038/s41598-019-49214-w
AHN SONG IH, SEI YOSHITAKA J., PARK HYUN-JI, KIM JINHWAN, RYU YUJUNG, CHOI JEONGMOON J., SUNG HAK-JOON, MACDONALD TOBEY J., LEVEY : "Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms", NATURE COMMUNICATIONS, vol. 11, no. 1, XP093081916, DOI: 10.1038/s41467-019-13896-7
WAN JIANDI, ZHOU SITONG, MEA HING JII, GUO YAOJUN, KU HANSOL, URBINA BRIANNA M.: "Emerging Roles of Microfluidics in Brain Research: From Cerebral Fluids Manipulation to Brain-on-a-Chip and Neuroelectronic Devices Engineering", CHEMICAL REVIEWS, AMERICAN CHEMICAL SOCIETY, US, vol. 122, no. 7, 13 April 2022 (2022-04-13), US , pages 7142 - 7181, XP093081920, ISSN: 0009-2665, DOI: 10.1021/acs.chemrev.1c00480
VYSOKOV NICKOLAI, MCMAHON STEPHEN B., RAOUF RAMIN: "The role of NaV channels in synaptic transmission after axotomy in a microfluidic culture platform", SCIENTIFIC REPORTS, vol. 9, no. 1, XP093081928, DOI: 10.1038/s41598-019-49214-w
Attorney, Agent or Firm:
MUHANN PATENT & LAW FIRM (KR)
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