Title:
CROSSLINKED NUCLEOSIDE AND NUCLEOTIDE
Document Type and Number:
WIPO Patent Application WO/2015/125783
Kind Code:
A1
Abstract:
Disclosed are a crosslinked nucleoside and nucleotide. The nucleoside has a 2',4'-crosslinked structure, and is represented by formula (I). An oligonucleotide containing a 2',4'-crosslinked artificial nucleotide according to the present invention has nuclease resistance exceeding that of LNA and a binding affinity to single-strand RNA comparable to publically known 2',4'-BNA/LNA. In particular, use in a nucleic acid drug is anticipated due to the strong binding affinity to single-strand RNA in comparison to S-oligos.
Inventors:
OBIKA SATOSHI (JP)
YAMAGUCHI TAKAO (JP)
HORIBA MASAHIKO (JP)
WAKI REIKO (JP)
YAMAGUCHI TAKAO (JP)
HORIBA MASAHIKO (JP)
WAKI REIKO (JP)
Application Number:
PCT/JP2015/054308
Publication Date:
August 27, 2015
Filing Date:
February 17, 2015
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
C07H19/02; C07H21/00; C12N15/09
Domestic Patent References:
| WO2009006478A2 | 2009-01-08 | |||
| WO1998039352A1 | 1998-09-11 | |||
| WO2003068795A1 | 2003-08-21 | |||
| WO2005021570A1 | 2005-03-10 |
Other References:
SATOSHI OBIKA: "Soyaku Seeds to shite Kitai sereru Kakusan Iyakuhin -sono Tenbo to Kadai- 2. Tobu Kakyogata Kakusan no Iyaku eno Oyo", MEDICINE AND DRUG JOURNAL, vol. 48, 2012, pages 65 - 69, XP008184690
See also references of EP 3109254A4
See also references of EP 3109254A4
Attorney, Agent or Firm:
SHINDO, Takuya et al. (JP)
Takuya Shindo (JP)
Takuya Shindo (JP)
Download PDF: