Title:
CROSSLINKED PRODUCT OF AMYLOID-β PROTEIN (Aβ) ABLE TO BE SUBSTITUTE FOR AMYLOSPHEROID (ASPD), AND ANALYSIS OF ASPD
Document Type and Number:
WIPO Patent Application WO/2021/100744
Kind Code:
A1
Abstract:
Provided are a substance able to be a substitute for an amylospheroid (ASPD) and a method for analyzing ASPD. One embodiment of the present disclosure relates to a substance in which the amyloid-β protein (Aβ) is crosslinked by means of a crosslinking agent having a spacer arm length of 4-50 Å or a crosslinking agent having 1-13 oxyethylene groups (-CH2CH2O-) and/or oxypropylene groups (-CH2CH2CH2O-) as a spacer arm. Another embodiment of the present disclosure relates to a method for analyzing ASPD in which the abovementioned substance is used as a reference material.
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Inventors:
HOSHI MINAKO
ARAI YOSHIE
MACHIDA KIYOTAKA
ARAI YOSHIE
MACHIDA KIYOTAKA
Application Number:
PCT/JP2020/042938
Publication Date:
May 27, 2021
Filing Date:
November 18, 2020
Export Citation:
Assignee:
TAO HEALTH LIFE PHARMA CO LTD (JP)
International Classes:
A61K39/00; A61K47/60; A61P25/00; A61P25/28; A61P37/04; C07K14/47; G01N33/50; G01N33/53; G01N33/531; G01N33/543; G01N33/547
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| WO2009057664A1 | 2009-05-07 | |||
| WO1999041279A2 | 1999-08-19 | |||
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Foreign References:
| JP2008531635A | 2008-08-14 | |||
| JP2019518196A | 2019-06-27 | |||
| JP2008291025A | 2008-12-04 | |||
| US20090246191A1 | 2009-10-01 |
Other References:
HOSHI ET AL.: "Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-36", PNAS, vol. 100, no. 116370-6375, 27 May 2003 (2003-05-27)
OHNISHI ET AL.: "Na, K-ATPase a3 is a death target of Alzheimer patient amyloid-6 assembly", PNAS, vol. 112, no. 32, 11 August 2015 (2015-08-11), pages E4465 - E4474, XP055429651, DOI: 10.1073/pnas.1421182112
NOGUCHI ET AL.: "Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains", J BIOL CHEM, vol. 284, no. 47, 20 November 2009 (2009-11-20), pages 32895 - 905, XP002675882, DOI: 10.1074/JBC.M109.000208
See also references of EP 4062929A4
OHNISHI ET AL.: "Na, K-ATPase a3 is a death target of Alzheimer patient amyloid-6 assembly", PNAS, vol. 112, no. 32, 11 August 2015 (2015-08-11), pages E4465 - E4474, XP055429651, DOI: 10.1073/pnas.1421182112
NOGUCHI ET AL.: "Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains", J BIOL CHEM, vol. 284, no. 47, 20 November 2009 (2009-11-20), pages 32895 - 905, XP002675882, DOI: 10.1074/JBC.M109.000208
See also references of EP 4062929A4
Attorney, Agent or Firm:
IKEUCHI & PARTNERS (JP)
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