Title:
CROSSLINKING NUCLEOSIDE AND NUCLEOTIDE
Document Type and Number:
WIPO Patent Application WO/2016/017422
Kind Code:
A1
Abstract:
Disclosed are a crosslinking nucleoside and nucleotide. This nucleoside has a 2',4'-crosslinking structure, and is represented by formula (I) or (I'). An oligonucleotide containing this 2',4'-crosslinking artificial nucleotide exhibits a binding affinity to single-strand RNA comparable to that of oligonucleotides containing conventional 2',4'-crosslinking artificial nucleotides. An oligonucleotide according to the present invention is useful, for example, as a nucleic acid drug material.
Inventors:
HARI YOSHIYUKI (JP)
OBIKA SATOSHI (JP)
OSAWA TAKASHI (JP)
OBIKA SATOSHI (JP)
OSAWA TAKASHI (JP)
Application Number:
PCT/JP2015/070201
Publication Date:
February 04, 2016
Filing Date:
July 14, 2015
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
C07H19/10; C07H21/02; C12N15/09; A61K31/7072; A61P31/12; A61P35/00; A61P43/00
Domestic Patent References:
| WO1998039352A1 | 1998-09-11 | |||
| WO2000047599A1 | 2000-08-17 |
Foreign References:
| JP2011155914A | 2011-08-18 | |||
| JP2002521310A | 2002-07-16 |
Attorney, Agent or Firm:
SHINDO, Takuya et al. (JP)
Takuya Shindo (JP)
Takuya Shindo (JP)
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