CRYSTAL OF CYTIDINE DIPHOSPHATE CHOLINE AND PRODUCTION PROCESS THEFEFOR

Title:

CRYSTAL OF CYTIDINE DIPHOSPHATE CHOLINE AND PRODUCTION PROCESS THEFEFOR

Document Type and Number:

WIPO Patent Application WO/2018/066690

Kind Code:

A1

Abstract:

The purpose of the present invention is to provide: crystals of cytidine diphosphate choline which contain no methanol and have improved powder properties; and a process for producing the crystals. The process according to the present invention comprises precipitating crystals of cytidine diphosphate choline in an aqueous solution containing cytidine diphosphate choline dissolved therein, collecting the precipitated crystals of cytidine diphosphate choline, and washing the collected crystals of cytidine diphosphate choline with an aqueous solution of an organic solvent other than methanol, the aqueous solution having a water content of 5-50 vol%. Thus, crystals of cytidine diphosphate choline which contain no methanol and have improved powder properties can be obtained.

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Inventors:

FUKUMOTO KAZUNARI (JP)

Application Number:

PCT/JP2017/036463

Publication Date:

April 12, 2018

Filing Date:

October 06, 2017

Export Citation:

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Assignee:

KYOWA HAKKO BIO CO LTD (JP)

International Classes:

C07H19/10

Domestic Patent References:

WO2007018259A1	2007-02-15
WO2008047792A1	2008-04-24

Foreign References:

JPS4637749B1
US3687932A	1972-08-29
CN101538300A	2009-09-23
JPS5132630B1	1976-09-14
JPS51108076A	1976-09-25
JP6166786B2	2017-07-19
JPS5132630B1	1976-09-14
JPS647367A	1989-01-11
JP3369236B2	2003-01-20
JP4977608B2	2012-07-18
JP2016197695A	2016-11-24

Other References:

YAMAGISHI, TAKAMICHI: "Passage, A Laboratory Guide to Organic Chemical Experiment for Young Chemists", A LABORATORY GUIDE TO ORGANIC CHEMICAL EXPERIMENT FOR YOUNG CHEMISTS, 10 March 2010 (2010-03-10), pages 132 - 133, XP009515254, ISBN: 978-4-06-154375-1
CYTIDINE 5' -DIPHOSPHATE CHOLINE MONOHYDRATE, vol. 34, no. 3, 1975, pages 358 - 368, XP9515009
See also references of EP 3524613A4

Attorney, Agent or Firm:

EIKOH PATENT FIRM, P.C. (JP)

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