Title:
CRYSTAL FORM A OF 2'-FLUORO-4'-SUBSTITUTED NUCLEOSIDE ANALOG I AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/186588
Kind Code:
A1
Abstract:
Disclosed is a crystal form A of a 2'-fluoro-4'-substituted nucleoside analog I, wherein same falls within the field of pharmaceutical chemistry. The crystal form A has the following structure: (I). The CuKα-XRPD pattern of the crystal form A of the compound I is as shown in figure 2, wherein the crystal form A has a good stability and can easily be uniformly mixed with auxiliary materials. The crystal form A of the compound I is mixed with the auxiliary materials, so that the uniformity thereof in tablets is increased, and same is conducive to controlling the drug quality and ensuring the drug efficacy. The crystal form A is used for preparing anti-HBV or anti-HCV or anti-HIV drugs or anti-tumor drugs.
Inventors:
CHANG JUNBIAO (CN)
DU JINFA (CN)
GE DONGXU (CN)
DU JINFA (CN)
GE DONGXU (CN)
Application Number:
PCT/CN2019/083217
Publication Date:
September 24, 2020
Filing Date:
April 18, 2019
Export Citation:
Assignee:
HENAN GENUINE BIOTECH CO LTD (CN)
International Classes:
C07H19/06; A61K31/7068; A61K31/7076; A61P31/18
Domestic Patent References:
| WO2005003174A1 | 2005-01-13 | |||
| WO2001060315A2 | 2001-08-23 |
Foreign References:
| CN101177442A | 2008-05-14 | |||
| CN102000103A | 2011-04-06 | |||
| CN108503681A | 2018-09-07 | |||
| CN200710137548A | 2007-08-07 |
Other References:
WANG, QIANG ET AL.: "FNC, a Novel Nucleoside Analogue Inhibits Cell Proliferation and Tumor Growth in a Variety of Human Cancer Cells", BIOCHEMICAL PHARMACOLOGY, vol. 81, 8 January 2011 (2011-01-08), XP028166488, DOI: 20191203145518X
EUR. J. MED. CHEM, 2011, pages 464178
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol. 15, 2014, pages 6829
WANG, Q. ET AL., BIOCHEMICAL PHARMACOLOGY, vol. 81, 2011, pages 848
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol. 15, 2014, pages 6829
See also references of EP 3939984A4
EUR. J. MED. CHEM, 2011, pages 464178
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol. 15, 2014, pages 6829
WANG, Q. ET AL., BIOCHEMICAL PHARMACOLOGY, vol. 81, 2011, pages 848
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol. 15, 2014, pages 6829
See also references of EP 3939984A4
Attorney, Agent or Firm:
ZHENGZHOU LIANKE PATENT AGENCY (COMMON PARTNERSHIP) (CN)
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