Title:
CRYSTAL FORM OF BROMODOMAIN PROTEIN INHIBITOR DRUG, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/103726
Kind Code:
A1
Abstract:
Provided are a crystal form of a bromodomain protein inhibitor 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one represented by Formula I, a preparation method and a use thereof. The present invention belongs to the field of medicine.
The crystal forms are crystal form CS2, crystal form CS8, crystal form CS13, crystal form CS20, crystal form CS1, crystal form CS7, crystal form CS9, crystal form CS11, and crystal form CS4, and can be used to prepare drugs for treating cardiovascular, cholesterol, or lipid-related disorders.
Inventors:
CHEN MINHUA (CN)
ZHANG YANFENG (CN)
ZHAI XIAOTING (CN)
YAN KAIQIANG (CN)
ZHANG XIAOYU (CN)
ZHANG YANFENG (CN)
ZHAI XIAOTING (CN)
YAN KAIQIANG (CN)
ZHANG XIAOYU (CN)
Application Number:
PCT/CN2017/115143
Publication Date:
June 14, 2018
Filing Date:
December 08, 2017
Export Citation:
Assignee:
CRYSTAL PHARMACEUTICAL SUZHOU CO LTD (CN)
International Classes:
C07D413/06; A61K31/517; A61P3/10; A61P5/38; A61P9/00; A61P9/10; C07D471/04
Foreign References:
| CN101970416A | 2011-02-09 | |||
| CN101641339A | 2010-02-03 | |||
| CN101641339A | 2010-02-03 |
Other References:
PICAUD SARAH ET AL.: "RVX-208, an inhibitor of BET transcriptional regulato- rs with selectivity for the second bromodomain", PNAS, 3 December 2013 (2013-12-03), pages 19754 - 19759, XP002737220, DOI: doi:10.1073/pnas.1310658110
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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