CRYSTAL FORM OF BTK INHIBITOR, ACID SALT THEREOF, AND CRYSTAL FORM OF ACID SALT THEREOF

WIPO Patent Application WO/2023/174300

A1

Disclosed in the present invention are a crystal form of a BTK inhibitor, an acid salt thereof, and a crystal form of the acid salt thereof. The crystal form of a compound of formula I in the present invention is a free alkali crystal form A of the compound of formula I, a free alkali crystal form C of the compound of formula I, a free alkali D of the compound of formula I, or a free alkali crystal form E of the compound of formula I. The crystal form of the BTK inhibitor, the acid salt thereof, and the crystal form of the acid salt thereof in the present invention have the advantages of low hygroscopicity and good stability, and have very important significance for drug development.

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ZHAO JINZHU (CN)
CAO YUDONG (CN)
ZHOU FUSHENG (CN)
ZHU LINDONG (CN)
LIU XIANGCHAO (CN)
LAN JIONG (CN)

PCT/CN2023/081427

September 21, 2023

March 14, 2023

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GENFLEET THERAPEUTICS SHANGHAI INC (CN)
ZHEJIANG GENFLEET THERAPEUTICS CO LTD (CN)

C07D471/14; A61K31/437; A61P29/00

WO2007002433A1	2007-01-04
WO2022063101A1	2022-03-31

CN107001362A

2017-08-01

NA SONG, XU DANDAN, JIN YANFEN, ZHENG MEI, YANG JIANKE: "Research Progress in Ibrutinib Derivatives", CHINA PHARMACIST, vol. 22, no. 12, 5 December 2019 (2019-12-05), pages 2270 - 2274, XP093092343

SHANGHAI BESHINING LAW OFFICE (CN)

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