Title:
CRYSTAL FORM OF FREE ALKALI OF NITROGEN-CONTAINING AROMATIC DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2021/197452
Kind Code:
A1
Abstract:
The present invention relates to a crystal form of the free alkali of nitrogen-containing aromatic derivatives. In particular, the present invention relates to a crystal form of the compound represented by the general formula (I), its preparation method and a pharmaceutical composition containing a therapeutically effective amount of the crystal form, and the use thereof as a protein tyrosine phosphatase-2C (SHP2) inhibitor in the treatment of diseases or conditions such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colorectal cancer.
Inventors:
ZHAN XIAOLAN (CN)
GUO LINSONG (CN)
GUO LINSONG (CN)
Application Number:
PCT/CN2021/085155
Publication Date:
October 07, 2021
Filing Date:
April 02, 2021
Export Citation:
Assignee:
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07D241/18; A61K31/495; A61P35/00; C07D471/10; C07D498/10
Domestic Patent References:
| WO2018172984A1 | 2018-09-27 | |||
| WO2019183367A1 | 2019-09-26 | |||
| WO2020073949A1 | 2020-04-16 | |||
| WO2019051084A1 | 2019-03-14 |
Foreign References:
| CN105916845A | 2016-08-31 | |||
| CN109983001A | 2019-07-05 | |||
| CN110143949A | 2019-08-20 | |||
| CN107922388A | 2018-04-17 | |||
| CN2019110314W | 2019-10-10 |
Other References:
See also references of EP 4129987A4
Attorney, Agent or Firm:
GE CHENG & CO.,LTD. (CN)
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