Title:
CRYSTAL FORM OF HYDROCHLORIDE OF PYRAZOLOHETEROARYL DERIVATIVE AND PREPARATION METHOD
Document Type and Number:
WIPO Patent Application WO/2019/223773
Kind Code:
A1
Abstract:
The present invention relates to a crystal form of a hydrochloride of a pyrazoloheteroaryl derivative and a preparation method. In particular, the present invention relates to crystal forms I and II of a dihydrochloride of a compound represented by formula (I), crystal forms A, B, and C of a monohydrochloride of the compound represented by formula (I), and a preparation method thereof. The crystal forms of the compound represented by formula (I) of the present invention have good crystal stability and can be better used for clinical treatment.
Inventors:
CAO XIAOLI (CN)
DU ZHENXING (CN)
WANG LIKUN (CN)
DU ZHENXING (CN)
WANG LIKUN (CN)
Application Number:
PCT/CN2019/088250
Publication Date:
November 28, 2019
Filing Date:
May 24, 2019
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D471/04; A61K31/395; A61P31/12; A61P35/00
Domestic Patent References:
| WO2008114008A1 | 2008-09-25 | |||
| WO2015162075A1 | 2015-10-29 | |||
| WO2005025583A2 | 2005-03-24 | |||
| WO2007093901A1 | 2007-08-23 | |||
| WO2008011406A2 | 2008-01-24 | |||
| WO2009091032A1 | 2009-07-23 | |||
| WO2010077613A1 | 2010-07-08 | |||
| WO2010133882A1 | 2010-11-25 | |||
| WO2011031965A1 | 2011-03-17 | |||
| WO2012080730A1 | 2012-06-21 | |||
| WO2002012224A2 | 2002-02-14 |
Foreign References:
| CN102272134A | 2011-12-07 | |||
| CN102666541A | 2012-09-12 | |||
| CN201810512563A | 2018-05-25 | |||
| CN2017113007W | 2017-11-27 |
Other References:
MAHLA, RS ET AL., FRONT IMMUNOL, vol. 4, 2013, pages 248
DIEBOLD S. S. ET AL., SCIENCE, vol. 303, 2004, pages 1529 - 1531
LUND J. M. ET AL., PNAS, vol. 101, 2004, pages 5598 - 5603
LIU Y-J, ANNU. REV. IMMUNOL., vol. 23, 2005, pages 275 - 306
See also references of EP 3808745A4
DIEBOLD S. S. ET AL., SCIENCE, vol. 303, 2004, pages 1529 - 1531
LUND J. M. ET AL., PNAS, vol. 101, 2004, pages 5598 - 5603
LIU Y-J, ANNU. REV. IMMUNOL., vol. 23, 2005, pages 275 - 306
See also references of EP 3808745A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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