Title:
CRYSTAL FORM OF KEY INTERMEDIATE OF BTK KINASE INHIBITOR AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/004401
Kind Code:
A9
Abstract:
The present invention relates to a crystal form of a key intermediate of a BTK kinase inhibitor and a preparation method therefor, and belongs to the technical field of medicines. The crystal form is a (R)-1-(1-(tert-butyloxyl)pyrrolidine-3-yl)-3-cyano-4-(4-(2,6-difluorophenoxyl)phenyl)-1H-pyrrole-2-ethyl formate crystal form II. The obtained (R)-1-(1-(tert-butyloxyl)pyrrolidine-3-yl)-3-cyano-4-(4-(2,6-difluorophenoxyl)phenyl)-1H-pyrrole-2-ethyl formate crystal form II has good chemical stability and crystal form stability, storage and transportation are facilitated, and moreover, the intermediate can be highly purified to obtain a sample with the purity of 99.7%, and the crystal form has important significance to quality control over BTK kinase inhibitor (R)-4-amino-1-(1-(butyl-2-alkynyl)pyrrolidine-3-yl)-3-(4-(2,6-difluorophenoxyl)phenyl)-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-ketone, and is simple in preparation process and suitable for industrial scale production.
Inventors:
LI CHAO (CN)
SUN PENG (CN)
TIAN BEIBEI (CN)
ZHANG XIN (CN)
SUN PENG (CN)
TIAN BEIBEI (CN)
ZHANG XIN (CN)
Application Number:
PCT/CN2020/100245
Publication Date:
May 06, 2021
Filing Date:
July 03, 2020
Export Citation:
Assignee:
SHANGHAI ZAIQI BIO TECH CO LTD (CN)
International Classes:
C07D207/34
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