Title:
CRYSTAL FORM OF MACROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/045360
Kind Code:
A1
Abstract:
The present invention relates to the technical field of drug synthesis. Disclosed are a crystal form of a macrocyclic compound, and a preparation method therefor and the use thereof. The macrocyclic compound is (6R, 16R)-9-fluoro-16-methyl-13-oxa-2,17,21,25-tetraazapentane [16.6.2.02,6.07,12.022,26]dihexadecane-1(25),7,9,11,18(26),19,21,23-octane-19-carbonitrile. The X-ray diffraction pattern of the crystal form has characteristic peaks at 2θ values of 9.49 ± 0.2, 10.60 ± 0.2, 11.54 ± 0.2, 14.10 ± 0.2, 17.09 ± 0.2, 19.15 ± 0.2, 20.30 ± 0.2, 22.85 ± 0.2, 23.89 ± 0.2, and 27.74 ± 0.2. The crystal form is hygroscopicity-free, and has a good stability and pharmacokinetic properties.
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Inventors:
GUO RUIZHI (CN)
WANG JIANSONG (CN)
LUO ZHIBO (CN)
HUANG HAIWEN (CN)
QIN FEI (CN)
WANG WEI (CN)
YE HAIHONG (CN)
QIAN RIBIN (CN)
WANG JIANSONG (CN)
LUO ZHIBO (CN)
HUANG HAIWEN (CN)
QIN FEI (CN)
WANG WEI (CN)
YE HAIHONG (CN)
QIAN RIBIN (CN)
Application Number:
PCT/CN2022/093322
Publication Date:
March 30, 2023
Filing Date:
May 17, 2022
Export Citation:
Assignee:
HITGEN INC (CN)
International Classes:
C07D471/04; A61P9/10; A61P11/06; A61P13/08; A61P13/10; A61P13/12; A61P17/10; A61P19/02; A61P19/08; A61P25/06; A61P25/16; A61P25/28; A61P35/00; A61P37/06; A61P37/08
Domestic Patent References:
| WO2010085597A1 | 2010-07-29 |
Foreign References:
| CN113754657A | 2021-12-07 | |||
| CN110386945A | 2019-10-29 | |||
| CN113121568A | 2021-07-16 | |||
| CN112174982A | 2021-01-05 | |||
| CN110386945A | 2019-10-29 |
Other References:
"China Pharmacopoeia", 2020, pages: 9103
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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