CRYSTAL FORM A OF NHE3 INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Title:

CRYSTAL FORM A OF NHE3 INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2020/181555

Kind Code:

A1

Abstract:

Crystal form A of N,N'-(10,17-dihydro-3,6,21,24-tetraoxa-9,11,16,18-tetrazohexahexane-1,26-di-yl)bis(4-(6,8-dichloro-2-methyl-1,2,3,-tetrahydroisoquinoline-4-yl). The crystal form has good light stability, high-temperature stability, and high-humidity stability.

Inventors:

REN GUOBIN (CN)
YI DONGXU (CN)
HUANG JIAJUN (CN)

Application Number:

PCT/CN2019/078165

Publication Date:

September 17, 2020

Filing Date:

March 14, 2019

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Assignee:

SHENZHEN RENTAI PHARMATECH LTD (CN)

International Classes:

C07D401/12; A61K31/4725; A61P1/04; C07D217/16

Domestic Patent References:

WO2019091503A1	2019-05-16
WO2018129557A1	2018-07-12

Foreign References:

CN102333759A	2012-01-25
CN105392483A	2016-03-09

Attorney, Agent or Firm:

SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD. (CN)

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