Title:
CRYSTAL FORM OF OXYTOCIN RECEPTOR INHIBITOR AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/242646
Kind Code:
A1
Abstract:
Provided are a polycrystal form of an oxytocin receptor (OTR) inhibitor compound 5-(3-(3-(6-fluoronaphthalen-1-yl)azetidin-1-yl)5-(methoxymethyl)-4H-1,2,4-triazol-4-yl)-2-methoxypyridine and a preparation method therefor. Relative to an amorphous form, the polycrystalline OTR inhibitor has higher purity and better chemical stability, having great significance in developing a drug suitable for industrial production and having good biological activity.
Inventors:
SHAO QIYUN (CN)
YANG JUNRAN (CN)
XU CHAO (CN)
DU ZHENXING (CN)
WANG JIE (CN)
YANG JUNRAN (CN)
XU CHAO (CN)
DU ZHENXING (CN)
WANG JIE (CN)
Application Number:
PCT/CN2019/091900
Publication Date:
December 26, 2019
Filing Date:
June 19, 2019
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/14; A61K31/397; A61K31/4196; A61P15/00
Domestic Patent References:
| WO2018113694A1 | 2018-06-28 | |||
| WO2006092731A1 | 2006-09-08 |
Foreign References:
| CN101107243A | 2008-01-16 |
Other References:
KARPENKO, L.A. ET AL.: "Selective Nonpeptidic Fluorescent Ligands for Oxytocin Receptor: Design, Synthesis, and Application to Time-Resolved FRET Binding Assay", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 5, 2 February 2015 (2015-02-02), pages 2547 - 2552, XP055498262, ISSN: 0022-2623, DOI: 10.1021/jm501395b
Attorney, Agent or Firm:
GE CHENG & CO.,LTD. (CN)
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