Title:
CRYSTAL FORM OF XEVINAPANT, METHOD FOR PREPARING SAME AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/022275
Kind Code:
A1
Abstract:
The present invention relates to a crystal form of compound Xevinapant and a method for preparing same, a pharmaceutical composition containing same, and use thereof in the preparation of an inhibitor drug for inhibitors of apoptosis protein and a drug for treating head and neck squamous cell carcinoma.
Inventors:
QIAN JIALE (CN)
HUANG CHUNXIANG (CN)
MENG LIPING (CN)
HUANG CHUNXIANG (CN)
MENG LIPING (CN)
Application Number:
PCT/CN2023/108830
Publication Date:
February 01, 2024
Filing Date:
July 24, 2023
Export Citation:
Assignee:
CRYSTAL PHARMACEUTICAL SUZHOU CO LTD (CN)
International Classes:
C07D487/00; A61K31/395; A61K31/55; A61P35/00
Domestic Patent References:
| WO2021148396A1 | 2021-07-29 |
Foreign References:
| CN111606970A | 2020-09-01 | |||
| CN114727984A | 2022-07-08 | |||
| CN101686981A | 2010-03-31 |
Other References:
QIAN CAI, HAIYING SUN, YUEFENG PENG, JIANFENG LU, ZANETA NIKOLOVSKA-COLESKA, DONNA MCEACHERN, LIU LIU, SU QIU, CHAO-YIE YANG, REBE: "A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 54, no. 8, 28 April 2011 (2011-04-28), pages 2714 - 2726, XP055084190, ISSN: 00222623, DOI: 10.1021/jm101505d
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