Title:
CRYSTAL OF PYROPHOSPHORIC ACID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2020/138481
Kind Code:
A1
Abstract:
The present invention provides a crystal of 1-{2-[(3S,4R)-1-[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidin-3-carbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl}piperidine-4-carboxylic acid, having a certain quality that can be used as a drug substance. Specifically, the present invention provides a crystal including equimolar amounts of 1-{2-[(3S,4R)-1-[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidin-3-carbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl}piperidine-4-carboxylic acid and phosphoric acid.
Inventors:
UEDA NAOKO (JP)
NAGATA HIROOMI (JP)
YOSHIDA TAKAHIRO (JP)
NAGATA HIROOMI (JP)
YOSHIDA TAKAHIRO (JP)
Application Number:
PCT/JP2019/051570
Publication Date:
July 02, 2020
Filing Date:
December 27, 2019
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
International Classes:
A61K31/454; A61P1/04; A61P1/16; A61P9/10; A61P13/12; A61P17/00; A61P17/06; A61P17/14; A61P19/02; A61P19/06; A61P25/00; A61P25/04; A61P27/02; A61P29/00; A61P31/00; A61P31/04; A61P31/18; A61P35/00; A61P37/02; A61P37/04; A61P43/00; C07D401/14
Domestic Patent References:
| WO2015182723A1 | 2015-12-03 | |||
| WO2015182723A1 | 2015-12-03 |
Foreign References:
| JP2017105765A | 2017-06-15 |
Other References:
See also references of EP 3903785A4
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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