Title:
CRYSTALLINE ACTIVE INGREDIENT MICROPARTICLES, METHOD FOR PRODUCING THE SAME AND USE THEREOF IN DRUGS
Document Type and Number:
WIPO Patent Application WO/2010/015298
Kind Code:
A3
Abstract:
The invention relates to a method for producing crystalline active ingredient microparticles, comprising the following steps: producing a suspension of primary particles of the active ingredient, a solution of the active ingredient, non-solvents for the active ingredient and inert molded articles, mixing the suspension, the active ingredient crystallizing out of the suspension, and removing the active ingredient in the form of product particles and finally drying the product particles. The primary particles and the product particles have a crystalline nature, are present in the most stable crystal modification of the active ingredient, have a crystal surface of 3 – 10 m2/g and the size distribution of the primary particles and product particles is d50 = 1 — 2 μm, d99 < 6 μm and d100 < 12 μm each. The invention further relates to active ingredient microparticles which can be obtained by said method and to a molded article product containing the active ingredient particles.
Inventors:
GRAWE DETLEF (DE)
GLIESING SABINE (DE)
EILERS ROBERT (DE)
GLIESING SABINE (DE)
EILERS ROBERT (DE)
Application Number:
PCT/EP2009/004724
Publication Date:
March 10, 2011
Filing Date:
June 30, 2009
Export Citation:
Assignee:
JESALIS PHARMA GMBH (DE)
GRAWE DETLEF (DE)
GLIESING SABINE (DE)
EILERS ROBERT (DE)
GRAWE DETLEF (DE)
GLIESING SABINE (DE)
EILERS ROBERT (DE)
International Classes:
A61K9/16
Domestic Patent References:
| WO2001014036A1 | 2001-03-01 |
Foreign References:
| US20030175187A1 | 2003-09-18 | |||
| EP0454138A2 | 1991-10-30 |
Attorney, Agent or Firm:
GEYER, FEHNERS & PARTNER (München, DE)
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