Title:
CRYSTALLINE FORM OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/171138
Kind Code:
A1
Abstract:
A crystalline form of a nitrogen-containing heterocyclic compound, a preparation method therefor and an application thereof. A crystalline form A of a compound represented by formula I, displaying a diffraction peak at 5.20±0.2°, 7.30±0.2°, 10.36±0.2°, 14.60±0.2°, 15.54±0.2°, 15.93±0.2°, 17.76±0.2°, 18.66±0.2°, 19.90±0.2°, 21.68±0.2°, and 22.64±0.2° in an X-ray powder diffraction spectrum represented by an angle of 2θ. The crystalline form has better stability. The pharmacokinetic property of the crystalline form A of the compound represented by formula I and a crystalline form C is better than that of an amorphous form.
Inventors:
LI DI (CN)
DUAN LINGJUN (CN)
XIA GUANGXIN (CN)
BI GUANGQING (CN)
KE YING (CN)
DUAN LINGJUN (CN)
XIA GUANGXIN (CN)
BI GUANGQING (CN)
KE YING (CN)
Application Number:
PCT/CN2022/075711
Publication Date:
August 18, 2022
Filing Date:
February 09, 2022
Export Citation:
Assignee:
SHANGHAI PHARMACEUTICALS HOLDING CO LTD (CN)
International Classes:
C07D487/04; A61K31/519; A61K31/5377; A61K31/541; A61P35/00; C07D519/00
Foreign References:
| CN107141293A | 2017-09-08 | |||
| CN109422755A | 2019-03-05 |
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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