Title:
CRYSTALLINE FORM OF OZANIMOD HYDROCHLORIDE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/042219
Kind Code:
A1
Abstract:
The present invention relates to a crystalline form of ozanimod hydrochloride and a preparation method therefor. The crystalline form of ozanimod hydrochloride provided by the present invention can be used to treat autoimmune diseases, particularly multiple sclerosis and ulcerative colitis. The crystalline form of ozanimod hydrochloride provided by the present invention has advantages in at least one aspect of solubility, melting point, stability, dissolubility, bioavailability, processing properties, and purification, provides new and better choices for preparation of ozanimod-containing pharmaceutical preparations and is of great significance for drug development.
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Inventors:
CHEN MINHUA (CN)
ZHANG YANFENG (CN)
ZHAI XIAOTING (CN)
YAN KAIQIANG (CN)
YANG CHAOHUI (CN)
ZHANG YANFENG (CN)
ZHAI XIAOTING (CN)
YAN KAIQIANG (CN)
YANG CHAOHUI (CN)
Application Number:
PCT/CN2018/102034
Publication Date:
March 07, 2019
Filing Date:
August 23, 2018
Export Citation:
Assignee:
CRYSTAL PHARMACEUTICAL SUZHOU CO LTD (CN)
International Classes:
A61K31/4245; C07D271/06; A61P37/00
Domestic Patent References:
| WO2015066515A1 | 2015-05-07 | |||
| WO2018050091A1 | 2018-03-22 | |||
| WO2017215617A1 | 2017-12-21 |
Foreign References:
| CN102762100A | 2012-10-31 | |||
| CN107840830A | 2018-03-27 | |||
| CN102762100A | 2012-10-31 |
Other References:
See also references of EP 3677575A4
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