Title:
CRYSTALLINE LENS HARDNESS ADJUSTMENT AGENT
Document Type and Number:
WIPO Patent Application WO/2022/107735
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel crystalline lens hardness adjustment agent that can be easily, simply, and safely ingested over an extended period of time, and that can effectively adjust the hardness of crystalline lenses and can prevent, alleviate, and improve deterioration of near vision and focus adjustment failure as seen in presbyopia caused by aging and various diseases. Said problem is solved by providing a crystalline lens hardness adjustment agent containing glucosyl hesperidin as an active ingredient.
Inventors:
NAKAZAWA YOSUKE (JP)
MORISHITA NAOKI (JP)
ENDO SHIN (JP)
MIYAKE MASAKI (JP)
MITSUZUMI HITOSHI (JP)
HAYANO MOTOSHI (JP)
TSUBOTA KAZUO (JP)
MORISHITA NAOKI (JP)
ENDO SHIN (JP)
MIYAKE MASAKI (JP)
MITSUZUMI HITOSHI (JP)
HAYANO MOTOSHI (JP)
TSUBOTA KAZUO (JP)
Application Number:
PCT/JP2021/041978
Publication Date:
May 27, 2022
Filing Date:
November 15, 2021
Export Citation:
Assignee:
HAYASHIBARA CO (JP)
TSUBOTA LAB INC (JP)
TSUBOTA LAB INC (JP)
International Classes:
A61P27/10; A23L33/105; A61K31/7048
Domestic Patent References:
| WO2016068278A1 | 2016-05-06 | |||
| WO2016031869A1 | 2016-03-03 | |||
| WO2015133483A1 | 2015-09-11 |
Foreign References:
| JP2019156742A | 2019-09-19 | |||
| JP2015140327A | 2015-08-03 | |||
| JPH10323196A | 1998-12-08 | |||
| JPH11346792A | 1999-12-21 |
Other References:
NAKAZAWA YOSUKE, AOKI MIKI, ISHIWA SHO, MORISHITA NAOKI, ENDO SHIN, NAGAI NORIAKI, YAMAMOTO NAOKI, FUNAKOSHI‑TAGO MEGUMI, TAMURA H: "Oral intake of α‑glucosyl‑hesperidin ameliorates selenite‑induced cataract formation", MOLECULAR MEDICINE REPORTS, SPANDIDOS PUBLICATIONS, GR, vol. 21, 1 January 2020 (2020-01-01), GR , pages 1258 - 1266, XP055931223, ISSN: 1791-2997, DOI: 10.3892/mmr.2020.10941
ANONYMOUS: "Laser cataract surgery with a nuclear hardness of 5 (the hardest crystalline lens)", AOYAMA EYE CLINIC, 16 June 2017 (2017-06-16), XP055931222, Retrieved from the Internet
ANONYMOUS: "Cataracts", KEIO HOSPITAL INFORMATION & PATIENT ASSISTANCE SERVICE (KOMPAS), JP, pages 1 - 3, XP009536886, Retrieved from the Internet [retrieved on 20211129]
ANONYMOUS: "Food with Function Claim "Healthy Body Hesperidin" To Be Released through Itoen Official Mail Order Store "Healthy Body" Beginning October 29", ITOEN PRESS RELEASE, JP, pages 1 - 2, XP009536872, Retrieved from the Internet
NAKAZAWA YOSUKE, AOKI MIKI, DOKI YURI, MORISHITA NAOKI, ENDO SHIN, NAGAI NORIAKI, FUNAKOSHI-TAGO MEGUMI, TAMURA HIROOMI: "Oral consumption of α-glucosyl-hesperidin could prevent lens hardening, which causes presbyopia", BIOCHEMISTRY AND BIOPHYSICS REPORTS, ELSEVIER, vol. 25, 1 March 2021 (2021-03-01), pages 100885, XP055931207, ISSN: 2405-5808, DOI: 10.1016/j.bbrep.2020.100885
ANONYMOUS: "Laser cataract surgery with a nuclear hardness of 5 (the hardest crystalline lens)", AOYAMA EYE CLINIC, 16 June 2017 (2017-06-16), XP055931222, Retrieved from the Internet
ANONYMOUS: "Cataracts", KEIO HOSPITAL INFORMATION & PATIENT ASSISTANCE SERVICE (KOMPAS), JP, pages 1 - 3, XP009536886, Retrieved from the Internet
ANONYMOUS: "Food with Function Claim "Healthy Body Hesperidin" To Be Released through Itoen Official Mail Order Store "Healthy Body" Beginning October 29", ITOEN PRESS RELEASE, JP, pages 1 - 2, XP009536872, Retrieved from the Internet
NAKAZAWA YOSUKE, AOKI MIKI, DOKI YURI, MORISHITA NAOKI, ENDO SHIN, NAGAI NORIAKI, FUNAKOSHI-TAGO MEGUMI, TAMURA HIROOMI: "Oral consumption of α-glucosyl-hesperidin could prevent lens hardening, which causes presbyopia", BIOCHEMISTRY AND BIOPHYSICS REPORTS, ELSEVIER, vol. 25, 1 March 2021 (2021-03-01), pages 100885, XP055931207, ISSN: 2405-5808, DOI: 10.1016/j.bbrep.2020.100885
Attorney, Agent or Firm:
SUMA PATENT OFFICE, P.C. (JP)
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