Title:
CRYSTALLINE STRUCTURE OF MU OPIOID RECEPTOR (MOR) AGONIST AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/073985
Kind Code:
A1
Abstract:
The invention provides a crystalline structure of mu opioid receptor (MOR) agonist and a preparation method therefor. Specifically, the invention provides (1S4S)-4-ethoxy-N-(2-((R)-9-(pyridine-2-yl)-6-oxaspiro [4.5] decano-9-yl) ethyl) -1,2,3,4-tetrahydronaphthalene-1-amine fumarate and a preparation method therefor. The crystalline form has good crystalline form stability, and is more suitable for clinical use.
Inventors:
WANG LIN (CN)
DU ZHENXING (CN)
DU ZHENXING (CN)
Application Number:
PCT/CN2019/110563
Publication Date:
April 16, 2020
Filing Date:
October 11, 2019
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
International Classes:
C07D407/14; A61K31/4433; A61P29/00
Domestic Patent References:
| WO2018188643A1 | 2018-10-18 | |||
| WO2017063509A1 | 2017-04-20 | |||
| WO2012129495A1 | 2012-09-27 |
Other References:
CHEN, XIAOTAO ET AL.: "Structure-Activity Relationships and Discovery of a G Protein Biased ยต Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6- oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, 24 September 2013 (2013-09-24), pages 8019 - 8031, XP055375432, DOI: 10.1021/jm4010829
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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