CRYSTALLOGRAPHICALLY STABLE AMORPHOUS CEPHALOSPORIN COMPOSITIONS AND PROCESS FOR PRODUCING THE SAME

Title:

CRYSTALLOGRAPHICALLY STABLE AMORPHOUS CEPHALOSPORIN COMPOSITIONS AND PROCESS FOR PRODUCING THE SAME

Document Type and Number:

WIPO Patent Application WO1999034832

Kind Code:

A8

Abstract:

Yellow and powdery compositions consisting of particles composed of a homogeneous mixture of amorphous cefditoren pivoxil with a water-soluble polymer additive and being orally administrable. These compositions can be obtained by dissolving crystalline cefditoren pivoxil and the water-soluble polymer additive in an aqueous solution of an acid, neutralizing, coprecipitating, and then drying the thus obtained precipitate followed by the recovery of the above-mentioned product in the form of particles.

Inventors:

ONODERA MASAHIRO (JP)
SUKEGAWA MASAMICHI (JP)
YASUI KIYOSHI (JP)
WATANABE TATSUO (JP)
SATO TOYOMI (JP)
MURAI YASUSHI (JP)
IINUMA KATSUHARU (JP)

Application Number:

PCT/JP1999/000020

Publication Date:

October 28, 1999

Filing Date:

January 07, 1999

Export Citation:

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Assignee:

MEIJI SEIKA KAISHA (JP)
ONODERA MASAHIRO (JP)
SUKEGAWA MASAMICHI (JP)
YASUI KIYOSHI (JP)
WATANABE TATSUO (JP)
SATO TOYOMI (JP)
MURAI YASUSHI (JP)
IINUMA KATSUHARU (JP)

International Classes:

A61K9/14; A61K31/545; A61K31/546; A61K47/38; A61P31/00; C07D501/00; C07D501/24; (IPC1-7): A61K47/38; C07D501/24

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