Title:
CRYSTALS OF VITAMIN D DERIVATIVE OR CRYSTALS OF SOLVATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/171801
Kind Code:
A1
Abstract:
Provided are crystals of a vitamin D derivative represented by formula (1) or crystals of a solvate of a vitamin D derivative represented by formula (1). Such crystals are useful as a pharmaceutical for promoting induction of differentiation of oligodendrocyte progenitor cells into oligodendrocytes.
Inventors:
SAITOH HIROSHI (JP)
TAKAHASHI SAORI (JP)
TAKAHASHI SAORI (JP)
Application Number:
PCT/JP2023/009366
Publication Date:
September 14, 2023
Filing Date:
March 10, 2023
Export Citation:
Assignee:
TEIJIN PHARMA LTD (JP)
International Classes:
C07D207/08; A61K31/59; A61P9/00; A61P19/00; A61P25/00; A61P25/16; A61P25/18; A61P25/24; A61P37/00; C07D265/30; C07D295/096
Domestic Patent References:
| WO2010053165A1 | 2010-05-14 | |||
| WO2022059684A1 | 2022-03-24 |
Other References:
ALERIE GUZMAN DE LA FUENTE, ET AL.: "Vitamin D receptor–retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation", THE JOURNAL OF CELL BIOLOGY, THE ROCKEFELLER UNIVERSITY PRESS, US, vol. 211, no. 5, 7 December 2015 (2015-12-07), US , pages 975 - 985, XP055610987, ISSN: 0021-9525, DOI: 10.1083/jcb.201505119
SHIRAZI HASTI ATASHI, RASOULI JAVAD, CIRIC BOGOLJUB, ROSTAMI ABDOLMOHAMAD, ZHANG GUANG-XIAN: "1,25-Dihydroxyvitamin D3 enhances neural stem cell proliferation and oligodendrocyte differentiation", EXPERIMENTAL AND MOLECULAR PATHOLOGY., ACADEMIC PRESS., US, vol. 98, no. 2, 1 April 2015 (2015-04-01), US , pages 240 - 245, XP093091612, ISSN: 0014-4800, DOI: 10.1016/j.yexmp.2015.02.004
MENGOZZI MANUELA, HESKETH ANDREW, BUCCA GISELDA, GHEZZI PIETRO, SMITH COLIN P.: "Vitamins D3 and D2 have marked but different global effects on gene expression in a rat oligodendrocyte precursor cell line", MOLECULAR MEDICINE, FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, WASHINGTON , DC, vol. 26, no. 1, 1 December 2020 (2020-12-01), Washington , DC , XP055913413, ISSN: 1076-1551, DOI: 10.1186/s10020-020-00153-7
SHIRAZI HASTI ATASHI, RASOULI JAVAD, CIRIC BOGOLJUB, ROSTAMI ABDOLMOHAMAD, ZHANG GUANG-XIAN: "1,25-Dihydroxyvitamin D3 enhances neural stem cell proliferation and oligodendrocyte differentiation", EXPERIMENTAL AND MOLECULAR PATHOLOGY., ACADEMIC PRESS., US, vol. 98, no. 2, 1 April 2015 (2015-04-01), US , pages 240 - 245, XP093091612, ISSN: 0014-4800, DOI: 10.1016/j.yexmp.2015.02.004
MENGOZZI MANUELA, HESKETH ANDREW, BUCCA GISELDA, GHEZZI PIETRO, SMITH COLIN P.: "Vitamins D3 and D2 have marked but different global effects on gene expression in a rat oligodendrocyte precursor cell line", MOLECULAR MEDICINE, FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, WASHINGTON , DC, vol. 26, no. 1, 1 December 2020 (2020-12-01), Washington , DC , XP055913413, ISSN: 1076-1551, DOI: 10.1186/s10020-020-00153-7
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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