Title:
CUBIC CYCLODEXTRIN FRAMEWORK-RGD COMPOSITION AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/147754
Kind Code:
A1
Abstract:
A cubic cyclodextrin framework-RGD composition (RGD-COF) and a preparation method therefor. Specifically, the cyclodextrin framework-RGD composition contains a cyclodextrin framework (COF) having a cubic structure and RGD, and can escape from phagocytosis and clearance of macrophages, enhance migration and adhesiveness to damaged blood vessels, and efficiently target and concentrate activated platelets at damaged blood vessel sites, having application prospects on targeted diagnosis and treatment of diseases associated with uncontrolled hemorrhage, atherosclerosis and cerebral apoplexy. By utilizing the advantage that a cyclodextrin-metal organic framework (CD-MOF) has controllable dimensions, a cubic cyclodextrin framework-RGD composition for nanoscale intravenous injection or microscale topical external use is provided.
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Inventors:
ZHANG JIWEN (CN)
HE YAPING (CN)
SU YONG (CN)
XU JIAN (CN)
WU LI (CN)
SUN XIAN (CN)
HE YAPING (CN)
SU YONG (CN)
XU JIAN (CN)
WU LI (CN)
SUN XIAN (CN)
Application Number:
PCT/CN2020/072261
Publication Date:
July 23, 2020
Filing Date:
January 15, 2020
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C08B37/16; A61K45/00; A61K47/40; A61P7/04; C08G81/00
Foreign References:
| CN104159573A | 2014-11-19 | |||
| CN107151329A | 2017-09-12 | |||
| CN107837401A | 2018-03-27 | |||
| CN107151328A | 2017-09-12 | |||
| CN201610125456A | 2016-03-04 |
Other References:
YAPING HE, JIAN XU, XIAN SUN, XIAOHONG REN, ABI MAHARJAN, PETER YORK, YONG SU, HAIYAN LI, JIWEN ZHANG: "Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting.", THERANOSTICS, vol. 9, no. 9, 13 April 2019 (2019-04-13), pages 2489 - 2504, XP055719647, DOI: 10.7150/thno.31159
ANDREW J. SHOFFSTALL, KRISTYN T. ATKINS, REBECCA E. GROYNOM, MATTHEW E. VARLEY, LYDIA M. EVERHART, MARGARET M. LASHOF-SULLIVAN, BL: "Intravenous Hemostatic Nanoparticles Increase Survival Following Blunt Trauma Injury", BIOMACROMOLECULES, vol. 13, no. 11, 21 September 2012 (2012-09-21), pages 3850 - 3857, XP055719651, ISSN: 1525-7797, DOI: 10.1021/bm3013023
ANDREW J SHOFFSTALL; LYDIA M EVERHART; MATTHEW E VARLEY; ERIC S SOEHNLEN; ADAM M SHICK; JEFFREY S USTIN; ERIN B LAVIK: "Tuning Ligand Density on Intravenous Hemostatic Nanoparticles Dramatically Increases Survival Following Blunt Trauma", BIOMACROMOLECULES, vol. 14, no. 8, 10 July 2013 (2013-07-10), pages 2790 - 2797, XP055184824, ISSN: 1525-7797, DOI: 10.1021/bm400619v
SAMBROOKRUSSELL ET AL.: "Molecular Cloning-A Laboratory Manual", 2001, CSHL PRESS
See also references of EP 3913003A4
ANDREW J. SHOFFSTALL, KRISTYN T. ATKINS, REBECCA E. GROYNOM, MATTHEW E. VARLEY, LYDIA M. EVERHART, MARGARET M. LASHOF-SULLIVAN, BL: "Intravenous Hemostatic Nanoparticles Increase Survival Following Blunt Trauma Injury", BIOMACROMOLECULES, vol. 13, no. 11, 21 September 2012 (2012-09-21), pages 3850 - 3857, XP055719651, ISSN: 1525-7797, DOI: 10.1021/bm3013023
ANDREW J SHOFFSTALL; LYDIA M EVERHART; MATTHEW E VARLEY; ERIC S SOEHNLEN; ADAM M SHICK; JEFFREY S USTIN; ERIN B LAVIK: "Tuning Ligand Density on Intravenous Hemostatic Nanoparticles Dramatically Increases Survival Following Blunt Trauma", BIOMACROMOLECULES, vol. 14, no. 8, 10 July 2013 (2013-07-10), pages 2790 - 2797, XP055184824, ISSN: 1525-7797, DOI: 10.1021/bm400619v
SAMBROOKRUSSELL ET AL.: "Molecular Cloning-A Laboratory Manual", 2001, CSHL PRESS
See also references of EP 3913003A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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