WO/2001/023349 | ACYLSULFONAMIDE DERIVATIVES |
JP2011500783 | Histone deacetylase inhibitor |
REKULA REDDY SANTOSH (IN)
SUDALAI ARUMUGAM (IN)
AMENDED CLAIMS received by the International Bureau on 10 September 2013(10.09.2013) We claim: 1. A one pot, single step process for the preparation of compound of general formula A and its isomers, Formula A starting from compounds of formula I, Formula I, wherein, R1 is hydrogen; R2 is selected from H, OMe, OTs, Obn; R3 is selected from H, OMe, OTs, OBn, N02; R* is selected from H, OMe, F; R5 is selected from H, N02, BR; R5' is selected from H, N02, CN; R* and R3 can together be selected as -0-CH.-0-; comprising the steps of reacting compound of formula I with CuCN in DMF, under reflux in presence of atmosphere to obtain the desired compound of Formula A in the range of 50% -90% yield. 2. The process according to claim 1, wherein said compound of formula I and CuCN are in the ratio of 1:2 to 1:3. 3. The process according to claim 1, wherein said isomers of compound of formula A are trans and cis isomers in the ratio of 3: 1 to 10:1. 4. The process according to claim 1, wherein the reaction is carried out at a temperature ranging from 140 to 160 °C. 5. The process according to claim 1, wherein the reaction is carried out for a time ranging from 10 to 15 hours. |